protein

FOSBPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOSBPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

FOSB is unique among Fos family members because it produces two major protein isoforms through alternative splicing: full-length FOSB (338 aa, ~39 kDa) and the truncated ΔFOSB (175 aa, ~25 kDa).

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🔬 Protein Info

Gene Symbol	FOSBPROTEIN
Protein Type	Transcription Factor
Function	is a transcription factor belonging to the Fos family of immediate early genes.
Subcellular Localization	** \| Nucleus \|
Molecular Weight	39 kDa
Amino Acids	338 aa
GeneCards	FOSBPROTEIN
Human Protein Atlas	FOSBPROTEIN
Basic region	Recognizes AP-1 binding sites (TGACTCA)
Leucine zipper	Forms coiled-coil dimers with Jun proteins
Dimerization	Forms exclusively heterodimers (not homodimers)
DNA binding	Requires heterodimer formation
Associated Diseases	neurodegeneration
Interactions	6-OHDA, Akt, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND
KG Connections	104 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

fosb-protein

protein · 1583 words

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Pathway Diagram

graph TD
    FOSBPROTEIN["FOSBPROTEIN"]
    neurodegeneration["neurodegeneration"]
    FOSBPROTEIN -->|"implicated_in"| neurodegeneration
    style FOSBPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning FOSBPROTEIN in their description or question text

No additional research found