protein

Akt

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Akt: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7813Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Akt is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 1391 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	AKT
Pathways	AUTOPHAGY, EV-A71 Infection, Inflammatory Cytokine Secretion, LIPID METABOLISM, Methamphetamine Toxicity
GeneCards	AKT
Human Protein Atlas	AKT
Associated Diseases	cancer, diabetes, neurodegeneration
Known Drugs/Compounds	MK2206, Akt inhibitors, Ipatasertib
Interactions	mTOR, TSC2, GSK3β, MTOR, PI3K, PRKCD
KG Connections	2093 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Akt["Akt"] -->|"phosphorylates"| TSC2["TSC2"]
    Akt["Akt"] -.->|"inhibits"| TSC2_1["TSC2"]
    Akt["Akt"] -->|"regulates"| M1_M2_polarization["M1/M2 polarization"]
    Akt["Akt"] -->|"activates"| mTOR["mTOR"]
    Akt["Akt"] -->|"regulates"| inflammatory_cytokines["inflammatory cytokines"]
    Akt["Akt"] -->|"regulates"| phagocytosis["phagocytosis"]
    MK2206["MK2206"] -.->|"inhibits"| Akt["Akt"]
    PI3K["PI3K"] -->|"activates"| Akt["Akt"]
    flavonoids["flavonoids"] -->|"regulates"| Akt["Akt"]
    Akt_inhibitors["Akt inhibitors"] -.->|"inhibits"| Akt["Akt"]
    style Akt fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (3886)

Target	Relation	Type	Str
MTOR	upstream_of	protein	0.95
PI3K/Akt/mTOR	involved_in	pathway	0.95
TSC2	phosphorylates	protein	0.90
TSC2	inhibits	protein	0.90
M1/M2 polarization	regulates	phenotype	0.90
mTOR	activates	protein	0.80
inflammatory cytokines	regulates	protein	0.80
phagocytosis	regulates	phenotype	0.80
autophagy	regulates	phenotype	0.80
GLUT1	phosphorylates	entity	0.80
PFKB3	phosphorylates	enzyme	0.80
MTOR	activates	gene	0.78
neuroprotection	activates	process	0.70
GSK3β	regulates	protein	0.70
GSK3β	activates	protein	0.70
apoptosis	inhibits	process	0.70
advanced glycation end products	regulates	process	0.70
glucose uptake	regulates	process	0.70
neuronal cell death	inhibits	process	0.70
cancer	associated_with	disease	0.70
diabetes	associated_with	disease	0.70
neurodegeneration	associated_with	disease	0.70
GSK3β	inhibits	protein	0.70
IPF	regulates	disease	0.70
Huntington	therapeutic_target	disease	0.60
Atherosclerosis	protects_against	disease	0.60
Pyroptosis	therapeutic_target	disease	0.60
Epilepsy	activates	disease	0.60
Atherosclerosis	biomarker_for	disease	0.60
Pi3K	interacts_with	pathway	0.55
Cholesterol	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Angiogenesis	interacts_with	pathway	0.55
Wnt	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Glycolysis	interacts_with	pathway	0.55
Proteasome	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Ubiquitin-Proteasome	interacts_with	pathway	0.55
Tgf-Β	interacts_with	pathway	0.55
Complement	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Insulin Signaling	interacts_with	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Immune Response	interacts_with	pathway	0.55
Circadian Rhythm	interacts_with	pathway	0.55
Ferroptosis	interacts_with	pathway	0.55
Endocytosis	interacts_with	pathway	0.55
Dna Methylation	interacts_with	pathway	0.55

Incoming (3927)

Source	Relation	Type	Str
PI3K	upstream_of	protein	0.95
MK2206	inhibits	drug	0.90
Ipatasertib	inhibits	drug	0.90
TSC2	binds	gene	0.80
PRKCD	activates	gene	0.80
PI3K	activates	protein	0.70
flavonoids	regulates	drug	0.70
Akt inhibitors	inhibits	drug	0.70
ROS	regulates	process	0.70
ACTB	inhibits	gene	0.60
P2RY12	inhibits	gene	0.60
APOA1	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
EIF4EBP1	inhibits	gene	0.60
LC3	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
ABCG1	inhibits	gene	0.60
SQSTM1	inhibits	gene	0.60
ABCA1	inhibits	gene	0.60
APOE	inhibits	gene	0.60
LOX	inhibits	gene	0.60
TP53	interacts_with	gene	0.60
EFNB1	interacts_with	gene	0.60
EPHB4	interacts_with	gene	0.60
SRC	interacts_with	gene	0.60
JUN	activates	gene	0.60
NTN1	activates	gene	0.60
OPTN	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
AKT1	regulates	gene	0.60
CALCOCO2	regulates	gene	0.60
CGAS	regulates	gene	0.60
CFTR	regulates	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	regulates	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR	0.451	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Trem2-dependent Insl3 regulation via Dap12-Syk-PI3K pathway: A new pathogenic me [PMID:41038403]	Ye S, Wu C, Huang S, Fan H, Zhang Z et a	Genomics	2025	0

Akt

Understanding Entity Pages

Summary

Wiki Pages (20)

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