Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABRA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GABRA3 encodes the alpha3 subunit of GABA-A receptors, primarily expressed in thalamus, brainstem, and subcortical structures, involved in inhibitory neurotransmission and implicated in Alzheimer's and Parkinson's disease.
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| Gene Symbol | GABRA3 |
| Full Name | Gamma-Aminobutyric Acid Type A Receptor Alpha3 Subunit |
| Chromosome | Xq28 |
| Protein Type | Receptor |
| Function | encodes a critical subunit of the GABA-A receptor, the primary inhibitory neurotransmitter receptor in the mammalian central nervous system. |
| Subcellular Localization | subcortical structures, including the thalamus, brainstem, hypothalamus, and spinal cord[@bmaier2007][@sieghart2006]. Th |
| Molecular Weight | 52 kDa |
| Amino Acids | 460 aa |
| Exons | 9 |
| UniProt ID | P10815 |
| NCBI Gene ID | 2567 |
| Ensembl ID | ENSG00000111666 |
| OMIM | 137143 |
| GeneCards | GABRA3 |
| Human Protein Atlas | GABRA3 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GABRA3["GABRA3"]
neurodegeneration["neurodegeneration"]
GABRA3 -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning GABRA3 in their description or question text
No additional research found