gene

GABRG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

GABRG1 encodes the gamma-1 subunit of GABA-A receptors, critical for inhibitory neurotransmission in the brain with implications for Alzheimer's disease and cognitive function.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	GABRG1
Full Name	GABA-A Receptor Subunit Gamma 1
Chromosome	4p12
Amino Acids	460 aa
UniProt ID	[P18507](https://www.uniprot.org/uniprot/P18507)
Ensembl ID	ENSG00000146228
GeneCards	GABRG1
Human Protein Atlas	GABRG1
Benzodiazepine sensitivity	Intermediate (γ1 < γ2)
Ethanol sensitivity	Enhanced
Zinc sensitivity	Modulated
Neurosteroid modulation	Responsive
Synaptic targeting	γ1 interacts with gephyrin for synaptic localization
Endocytic trafficking	Regulates receptor internalization
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GABRG1 — GABA-A Receptor Subunit Gamma 1

gene · 1671 words

→

Pathway Diagram

graph TD
    GABRG1["GABRG1"]
    neurodegeneration["neurodegeneration"]
    GABRG1 -->|"implicated_in"| neurodegeneration
    style GABRG1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABRG1 in their description or question text

No additional research found