GAL3ST1

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAL3ST1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GAL3ST1 (Galactose-3-O-Sulfotransferase 1) encodes cerebroside sulfotransferase, essential for sulfatide biosynthesis in myelin. Deficiency causes metachromatic leukodystrophy (MLD). Also involved in immune function, kidney biology, and cancer metastasis.

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graph TD
    GAL3ST1["<b>GAL3ST1</b>"]
    neurodegeneration["neurodegeneration"]
    GAL3ST1 -->|"implicated in"| neurodegeneration
    Als{"Als"}
    GAL3ST1 -->|"implicated in"| Als
    Cancer{"Cancer"}
    GAL3ST1 -->|"implicated in"| Cancer
    Immune_Function(["Immune Function"])
    GAL3ST1 -->|"regulates"| Immune_Function
    ROS["ROS"]
    GAL3ST1 ---|"interacts"| ROS
    style GAL3ST1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Als fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Cancer fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Immune_Function fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f