protein

STING1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STING1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1292Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

STING1 is a protein involved in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with AD, ALI, ALS. Connected to 592 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	STING1
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	DNA sensing: cGAS (cyclic GMP-AMP synthase) binds cytosolic dsDNA from any source — mitochondrial, nuclear, microbial, or retrotransposon-derived
Mechanism of Action	Small molecule agonists or antagonists of cGAS-STING pathway activation
Druggability	Low (0.40)
Clinical Stage	Phase II
Pathways	Akt, Autophagy, Immune Response, Wnt, innate_immune_response
UniProt ID	A0A494C1N5
Ensembl ID	ENSG00000184584
GeneCards	STING1
Human Protein Atlas	STING1
Associated Diseases	AD, ALI, ALS, AUTOIMMUNITY, Aging
Known Drugs/Compounds	cGAMP, PA treatment, palmitic acid, VS-X4, Palmitic Acid, rapamycin
Interactions	CGAS, DNASE2, TYPE_I_IFN, TAX1BP1, ATM, SNCAIP
SciDEX Target	View Target Profile (3 clinical trials)
SciDEX Hypotheses	Mitochondrial NAD+ Salvage Enhancement
KG Connections	1291 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: STING1 — PDB 4LOH Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STING1["STING1"] -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
    STING1["STING1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    STING1["STING1"] -->|"interacts"| CGAS["CGAS"]
    STING1["STING1"] -->|"interacts"| DNASE2["DNASE2"]
    STING1["STING1"] -->|"co discussed"| C3["C3"]
    STING1["STING1"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    MITOCHONDRIAL_DNA["MITOCHONDRIAL_DNA"] -->|"activates"| STING1["STING1"]
    CGAS_1["CGAS"] -->|"interacts"| STING1["STING1"]
    DNASE2_2["DNASE2"] -->|"interacts"| STING1["STING1"]
    MMP9["MMP9"] -->|"co discussed"| STING1["STING1"]
    style STING1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (632)

Target	Relation	Type	Str
Savi	causes	disease	0.95
Type I Interferon Signaling	activates	pathway	0.95
IRF3	activates	protein	0.90
type I interferon	associated_with	protein	0.90
DNA Sensing Pathway	mediates	pathway	0.90
Type I Interferonopathy	causes	disease	0.90
Interferon-Stimulated Genes	upregulates	pathway	0.90
INTERFERON ALPHA	upregulates	protein	0.90
Autoimmunity	associated_with	disease	0.90
Macroautophagy	activates	process	0.90
PD-L1	associated_with	protein	0.90
TYPE_I_IFN	activates	protein	0.87
Ferroptotic Cell Death	mediates	process	0.85
Lipid Accumulation	regulates	phenotype	0.85
MTORC1 Complex Formation	mediates	process	0.85
Niemann-Pick Disease Type C	mediates	disease	0.85
Autophagy	mediates	process	0.85
MTORC1	activates	protein	0.82
TRAF6	interacts_with	protein	0.80
autophagy	associated_with	phenotype	0.80
lysosome-dependent cell death	associated_with	phenotype	0.80
SQSTM1	interacts_with	protein	0.80
GPX4	regulates	gene	0.80
NF-κB	activates	protein	0.80
MAPK	activates	protein	0.80
NEURODEGENERATION	causes	gene	0.80
FERROPTOSIS	causes	gene	0.80
NFKB	regulates	gene	0.80
BRAIN INFLAMMATION	causes	gene	0.80
autophagy pathway	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
neuroinflammation	triggers	process	0.80
Nonalcoholic Steatohepatitis	involved_in	disease	0.75
Als	activates	disease	0.75
Autoimmune	activates	disease	0.75
Als	therapeutic_target	disease	0.75
Infection	regulates	disease	0.75
AUTOPHAGY	activates	pathway	0.74
lipophagy	inhibits	pathway	0.72
SAVI	causes	disease	0.72
CGAS	activates	gene	0.70
ferroptosis	regulates	phenotype	0.70
neuroinflammation	regulates	process	0.70
immune response	activates	process	0.70
cardiac function	regulates	process	0.70
TBK1	activates	protein	0.70
tau-induced synaptic loss	activates	process	0.70
low-grade inflammation	regulates	process	0.70

Incoming (660)

Source	Relation	Type	Str
TLR2	regulates	protein	0.90
cGAS	activates	protein	0.90
cyclic GMP-AMP	activates	protein	0.90
palmitic acid	activates	drug	0.90
STIM1	binds	gene	0.90
Lipotoxicity	activates	process	0.90
Palmitic Acid	activates	compound	0.90
Mitochondrial Dna Stress	activates	process	0.90
h-1a34778f	targets_gene	hypothesis	0.90
h-3da804f5	targets_gene	hypothesis	0.90
h-bbe4540f	targets_gene	hypothesis	0.90
Mitochondrial DNA Stress	activates	process	0.85
SQSTM1	mediates	protein	0.85
CSNK1A1	phosphorylates	protein	0.85
PA treatment	activates	drug	0.80
h-1a34778f	targets	hypothesis	0.80
LC3	regulates	gene	0.80
ATG	activates	gene	0.80
ATG	regulates	gene	0.80
ROS	regulates	gene	0.80
MTORC1	regulates	gene	0.80
rapamycin	targets	drug	0.80
h-bbe4540f	targets	hypothesis	0.80
MITOCHONDRIAL_DNA	activates	gene	0.72
PA	activates	drug	0.72
mtDNA_stress	activates	phenotype	0.72
CGAS	activates	gene	0.72
cGAMP	activates	drug	0.72
CSNK1A1	inhibits	gene	0.72
AUTOPHAGY	inhibits	pathway	0.72
NDP52	interacts_with	gene	0.70
SQSTM1	activates	gene	0.70
STAT3	regulates	protein	0.70
NGLY1	activates	gene	0.70
VS-X4	inhibits	drug	0.70
RB1	activates	gene	0.70
ATM	regulates	gene	0.70
BECN1	regulates	gene	0.70
JNK	regulates	gene	0.70
MAP1LC3B	regulates	gene	0.70
NBR1	regulates	gene	0.70
OPTN	regulates	gene	0.70
RB1	regulates	gene	0.70
MTOR	regulates	gene	0.70
CGAS	regulates	gene	0.70
DDIT3	regulates	gene	0.70
EIF2AK3	regulates	gene	0.70
ERN1	regulates	gene	0.70
FIP200	regulates	gene	0.70
RB1CC1	regulates	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial NAD+ Salvage Enhancement	0.426	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (2)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107]	Lan T, Shang D, Lin L, Wang H, Zou J et	Autophagy	2026
cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960]	Fazal F, Dar NJ, Ahamad S, Khan S, Bano	Mol Aspects Med	2026
Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397]	Lu C, Wang W, Fu YX	Nat Rev Cancer	2026
CircZBTB44-Encoded Peptide ZBTB44-342aa Alleviates Aortic Valve Calcification Vi [PMID:41487094]	Hu D, Lin Y, Huang H, Xian G, Chen Y et	Circ Res	2026
Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200]	Li D, Cui G, Yang K, Lu C, Jiang Y et al	Nat Cell Biol	2026
cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413]	Solomon J, Mandal S, Aran KR	Gene	2026
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867]	Li L, Ye Q, Ma J, Wang Z, Liu T et al.	Cancer Cell	2026
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026
EsxN drives ISG15-mediated dsDNA release to activate cGAS-STING signaling and pr [PMID:41738749]	Zhang Q, Abudukadier A, Chen H, Xiong L,	Microbiol Spectr	2026
Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243]	Zhang M, Lan Y, Yue Q, He J, Li L et al.	J Nanobiotechnology	2026
African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral [PMID:41937559]	Li X, Ren B, Zhang D, Dan M, Liu D et al	Autophagy	2026
Microvesicle release drives cycles of mitophagy flux disruption and inflammatory [PMID:41941625]	Song R, Ma Y, Wan J, Hao S, Chen B et al	Proc Natl Acad Sci U S A	2026

STING1

Understanding Entity Pages

Summary

Wiki Pages (21)

STING1 Gene

mitochondrial-dynamics

cGAS-STING Pathway Dysregulation Hypothesis in Parkinson's Disease

Neuroinflammation Targeting Therapies

ATF6 - Activating Transcription Factor 6

POLG2 Gene — DNA Polymerase Gamma 2, Accessory Subunit

casp3

POLG — DNA Polymerase Subunit Gamma

Mitochondrial Dynamics in Neurodegeneration

CGAS Gene

Companies

cGAS-STING Inhibitor Therapy for Neurodegeneration

Endothelial Nitric Oxide Synthase (NOS3)

AD cGAS-STING and Innate Immune Pathway Companies

TRAF6 Protein

CFTR Gene

ATP2A2 Gene

plin3

Age-Sensitive Cortical Vulnerability in Parkinson's Disease

TBK1-Mediated Neuroinflammation Hypothesis — Impaired Autophagy and Innate Immune Dysregulation in FTD/ALS

IRF3 Protein