gene

CDKN2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDKN2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

467Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CDKN2A is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, activates. Associated with Aging, Als, Alzheimer. Connected to 223 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CDKN2A
Chromosome	9p21.3
Function	is a 156-amino acid protein composed of ankyrin repeat domains that adopt a highly twisted, left-handed helix structure[@li2019].
Molecular Weight	16 kDa
Amino Acids	156 aa
Pathways	Glycolysis, Tgf-Β
UniProt ID	P42771
NCBI Gene ID	1029
Ensembl ID	ENSG00000147883
GeneCards	CDKN2A
Human Protein Atlas	CDKN2A
p12^INK4a^	Alternatively spliced variant with truncated N-terminus
Associated Diseases	Aging, Als, Alzheimer, Atherosclerosis, Cancer, Carcinoma
Known Drugs/Compounds	rapamycin
Interactions	TLR4, TNC, NTRK2, PAK1, KCNK2, CD44
SciDEX Hypotheses	Senescence-Tau Decoupling Therapy
KG Connections	467 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDKN2A — AlphaFold P42771 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| cell_cycle_progression["cell cycle progression"]
    CDKN2A -->|"causes"| ESCC["ESCC"]
    CDKN2A -->|"target for"| Carcinoma["Carcinoma"]
    CDKN2A -->|"target for"| Cancer["Cancer"]
    CDKN2A -->|"target for"| Tumor["Tumor"]
    CDKN2A -->|"activates"| Als["Als"]
    CDKN2A -->|"expressed in"| Senescence["Senescence"]
    CDKN2A -->|"expressed in"| Lymphoma["Lymphoma"]
    FGFR1["FGFR1"] -->|"target for"| CDKN2A
    SOX2["SOX2"] -->|"target for"| CDKN2A
    CDK4["CDK4"] -->|"inhibits"| CDKN2A
    RB1["RB1"] -->|"inhibits"| CDKN2A
    BIN1["BIN1"] -->|"expressed in"| CDKN2A
    IGF1["IGF1"] -->|"regulates"| CDKN2A

Outgoing (363)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	associated_with	disease	0.95
cell cycle progression	inhibits	pathway	0.90
CD3+ T cells	expressed_in	cell_type	0.90
Autophagosome	associated_with	cell_type	0.90
ESCC	causes	disease	0.90
Cellular Senescence	associated_with	phenotype	0.90
Pulmonary Vascular Endothelial Cell Senescence	biomarker_for	process	0.85
Cancer	associated_with	disease	0.85
Tumor	activates	disease	0.85
Tumor	inhibits	disease	0.85
Cancer	activates	disease	0.85
Senescence	mediates	process	0.85
High-Grade Serous Ovarian Cancer	biomarker_for	disease	0.85
Tumor	risk_factor_for	disease	0.85
Senescence	biomarker_for	process	0.80
Cellular Senescence	biomarker_for	process	0.80
CANCER	associated_with	gene	0.80
CANCER	activates	gene	0.80
Tumor	therapeutic_target	disease	0.75
Tumor	associated_with	disease	0.75
Glioblastoma	associated_with	disease	0.75
Alzheimer	associated_with	disease	0.75
Als	activates	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	treats	disease	0.75
GBM	associated_with	gene	0.70
TP53	associated_with	gene	0.70
BRCA1	associated_with	gene	0.70
EGFR	associated_with	gene	0.70
OVERVIEW	treats	gene	0.70
TP53	activates	gene	0.70
CDK4	associated_with	gene	0.70
BAP1	associated_with	gene	0.70
POT1	associated_with	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
CANCER	treats	gene	0.70
P16	inhibits	gene	0.70
DNA	activates	gene	0.70
GENES	activates	gene	0.70
GENES	associated_with	gene	0.70
ROS	activates	gene	0.70
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Senescence	expressed_in	disease	0.65
Lymphoma	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Hypertension	regulates	disease	0.65

Incoming (104)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
SQSTM1	mediates	protein	0.95
MIR31HG	regulates	gene	0.90
h-08a79bc5	targets_gene	hypothesis	0.90
Polygonatum Sibiricum Polysaccharide	downregulates	compound	0.85
Autophagy Deficiency	causes	phenotype	0.85
DAPK1	regulates	gene	0.80
telomere shortening	upregulates	phenotype	0.80
SQSTM1	binds_to	gene	0.80
PTEN	associated_with	gene	0.80
MIR31HG	correlates_with	gene	0.75
TERT	associated_with	gene	0.70
FGFR1	therapeutic_target	gene	0.60
SOX2	therapeutic_target	gene	0.60
CDK4	inhibits	gene	0.60
RB1	inhibits	gene	0.60
EGR4	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
BIN1	expressed_in	gene	0.60
IGF1	regulates	gene	0.60
KEAP1	therapeutic_target	gene	0.60
TAU	associated_with	gene	0.60
PTEN	activates	gene	0.60
GBM	associated_with	gene	0.60
NOTCH1	therapeutic_target	gene	0.60
MYO5A	interacts_with	gene	0.60
NCOA4	interacts_with	gene	0.60
TERT	interacts_with	gene	0.60
BRAF	activates	gene	0.60
CDKN1A	associated_with	gene	0.60
CD19	therapeutic_target	gene	0.60
TP53	interacts_with	gene	0.60
SOX11	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
KMT2D	interacts_with	gene	0.60
NSD2	interacts_with	gene	0.60
NOTCH2	interacts_with	gene	0.60
NFKBIE	interacts_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
TP53	associated_with	gene	0.60
JUN	activates	gene	0.60
CAT	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
P38	activates	gene	0.60
IL6	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
SOX10	associated_with	gene	0.60
NF1	associated_with	gene	0.60
FAS	activates	gene	0.60
FOXO1	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Senescence-Tau Decoupling Therapy	0.410	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Uncovering the signatures of aging and senescence in the human dorsolateral pref [PMID:41576945]	Sloan NX, Mares J, Daly AC, Grier S, Haq	Cell Genom	2026
The Diagnostic Trap in Radiation-Induced Mesothelioma: Kinetic-Morphological Dec [PMID:41595142]	Fujita N, Fujita K, Osumi H, Takefuji Y	Cancers	2026
The prognostic impact of CDKN2A/B hemizygous deletions in meningioma. [PMID:41671098]	Ippen FM, Hielscher T, Patel A, Friedel	Neuro Oncol	2026
Cdkn2a/p16Ink4a loss impairs Spatial memory independently of Alzheimer's-associa [PMID:41741874]	Stephan P, Plassard D, Keyes WM, Hérault	Cell Mol Life Sci	2026
Senolytic therapy ameliorates high-fat diet-induced hippocampal senescence and c [PMID:41895394]	Xia X, Yi F, Zhang R, Wu R, Zhang X et a	Exp Neurol	2026

CDKN2A

Understanding Entity Pages

Summary

Wiki Pages (21)

cdkn2a

DDX3X Gene

Cellular Senescence in Neurodegeneration

Longevity and Rejuvenation Therapies Landscape

Cellular Senescence in Neurodegeneration

ataxia-telangiectasia

TrkB Protein

Astrocyte Senescence Pathway in Neurodegeneration

CBS Microglial Neuroimmune Axis

Cyclin E2 (CCNE2) Protein

Senolytic Therapies for Parkinson's Disease

Cellular Senescence Hypothesis in Parkinson's Disease

Cellular Senescence in Corticobasal Syndrome

DCC

MAP2K2 Gene

CDKN2A Protein

Senescent Cell Clearance in Neurodegeneration

PMS2 — DNA Mismatch Repair Protein PMS2

cellular-senescence-4r-tauopathies

Innate Immune Response in Neurodegeneration