gene

CDKN2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDKN2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

458Connections

3Hypotheses

8Analyses

50Outgoing

50Incoming

0Experiments

15Debates

Summary

CDKN2A is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, activates. Associated with Aging, Als, Alzheimer. Connected to 223 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CDKN2A
Chromosome	9p21.3
Function	is a 156-amino acid protein composed of ankyrin repeat domains that adopt a highly twisted, left-handed helix structure[@li2019].
Molecular Weight	16 kDa
Amino Acids	156 aa
Pathways	Glycolysis, Tgf-Β
UniProt ID	P42771
NCBI Gene ID	1029
Ensembl ID	ENSG00000147883
GeneCards	CDKN2A
Human Protein Atlas	CDKN2A
p12^INK4a^	Alternatively spliced variant with truncated N-terminus
Associated Diseases	Aging, Als, Alzheimer, Atherosclerosis, Cancer, Carcinoma
Known Drugs/Compounds	rapamycin
Interactions	AGING, AKT, AKT3, AND, APC, APOPTOSIS
SciDEX Hypotheses	Senescence-Tau Decoupling Therapy Hippocampal-Cortical Transcriptomic Divergence Rev
KG Connections	458 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDKN2A — AlphaFold P42771 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

cdkn2a

gene · 1625 words

→

CDKN2A Protein

protein · 2330 words

→

Pathway Diagram

graph TD
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| cell_cycle_progression["cell cycle progression"]
    CDKN2A -->|"causes"| ESCC["ESCC"]
    CDKN2A -->|"target for"| Carcinoma["Carcinoma"]
    CDKN2A -->|"target for"| Cancer["Cancer"]
    CDKN2A -->|"target for"| Tumor["Tumor"]
    CDKN2A -->|"activates"| Als["Als"]
    CDKN2A -->|"expressed in"| Senescence["Senescence"]
    CDKN2A -->|"expressed in"| Lymphoma["Lymphoma"]
    FGFR1["FGFR1"] -->|"target for"| CDKN2A
    SOX2["SOX2"] -->|"target for"| CDKN2A
    CDK4["CDK4"] -->|"inhibits"| CDKN2A
    RB1["RB1"] -->|"inhibits"| CDKN2A
    BIN1["BIN1"] -->|"expressed in"| CDKN2A
    IGF1["IGF1"] -->|"regulates"| CDKN2A

Outgoing (360)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CDKN2A	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	associated_with	disease	0.95
Autophagosome	associated_with	cell_type	0.90
cell cycle progression	inhibits	pathway	0.90
CD3+ T cells	expressed_in	cell_type	0.90
Cellular Senescence	associated_with	phenotype	0.90
p16INK4A	encodes	protein	0.90
ESCC	causes	disease	0.90
Senescence	mediates	process	0.85
Tumor	inhibits	disease	0.85
Tumor	activates	disease	0.85
Cancer	associated_with	disease	0.85
Tumor	associated_with	disease	0.85
High-Grade Serous Ovarian Cancer	biomarker_for	disease	0.85
Cancer	activates	disease	0.85
Pulmonary Vascular Endothelial Cell Senescence	biomarker_for	process	0.85
Senescence	biomarker_for	process	0.80
Cellular Senescence	biomarker_for	process	0.80
CANCER	associated_with	gene	0.80
CANCER	activates	gene	0.80
Glioblastoma	associated_with	disease	0.75
Als	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Cancer	treats	disease	0.75
Alzheimer	associated_with	disease	0.75
ALZHEIMER'S DISEASE	associated_with	gene	0.70
CANCER	treats	gene	0.70
GENES	associated_with	gene	0.70
OVERVIEW	treats	gene	0.70
TP53	activates	gene	0.70
GENES	activates	gene	0.70
cellular senescence	causes	process	0.70
P16	inhibits	gene	0.70
ROS	activates	gene	0.70
SASP	activates	pathway	0.70
EGFR	associated_with	gene	0.70
hippocampal neurodegeneration	biomarker_for	phenotype	0.70
microglial senescence	regulates	process	0.70
irreversible cell cycle arrest	regulates	mechanism	0.70
GBM	associated_with	gene	0.70
BRCA1	associated_with	gene	0.70
TP53	associated_with	gene	0.70
POT1	associated_with	gene	0.70
BAP1	associated_with	gene	0.70
OPC senescence	regulates	phenotype	0.70
pericyte senescence	regulates	process	0.70
CDK4	associated_with	gene	0.70
DNA	activates	gene	0.70

Incoming (98)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CDKN2A	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
SQSTM1	mediates	protein	0.95
h-08a79bc5	targets	hypothesis	0.90
MIR31HG	regulates	gene	0.90
Polygonatum Sibiricum Polysaccharide	downregulates	compound	0.85
Autophagy Deficiency	causes	phenotype	0.85
telomere shortening	upregulates	phenotype	0.80
DAPK1	regulates	gene	0.80
SQSTM1	binds_to	gene	0.80
PTEN	associated_with	gene	0.80
MIR31HG	correlates_with	gene	0.75
TERT	associated_with	gene	0.70
TAU	associated_with	gene	0.60
PTEN	activates	gene	0.60
OPTINEURIN	associated_with	gene	0.60
TP53	associated_with	gene	0.60
JUN	activates	gene	0.60
CAT	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
P38	activates	gene	0.60
IL6	associated_with	gene	0.60
FAS	activates	gene	0.60
FOXO1	activates	gene	0.60
APC	activates	gene	0.60
TP53	activates	gene	0.60
PMS2	activates	gene	0.60
CACNA1G	biomarker_for	gene	0.60
ARID1A	activates	gene	0.60
ATRX	associated_with	gene	0.60
CDKN1A	activates	gene	0.60
CDKN1A	inhibits	gene	0.60
CDKN1A	regulates	gene	0.60
AKT	activates	gene	0.60
CALCOCO2	activates	gene	0.60
ATM	associated_with	gene	0.60
CDK6	associated_with	gene	0.60
AKT3	activates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
MICRORNAS	associated_with	gene	0.60
P21	associated_with	gene	0.60
CYCLIN D1	therapeutic_target	gene	0.60
ROS	associated_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
AGING	activates	gene	0.60
P21	activates	gene	0.60
ROS	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Epigenetic Bivalency at CDKN2A Locus Distinguishes Senescent	0.630	neurodegeneration	How can senescent microglia be molecular
Senescence-Tau Decoupling Therapy	0.585	neurodegeneration	Gene expression changes in aging mouse b
Hippocampal-Cortical Transcriptomic Divergence Reveals Accel	0.519	alzheimer	Allen Mouse Brain Aging Atlas: cross-age

Mentioning Analyses (8)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Uncovering the signatures of aging and senescence in the human dorsolateral pref [PMID:41576945]	Sloan NX, Mares J, Daly AC, Grier S, Haq	Cell Genom	2026
The Diagnostic Trap in Radiation-Induced Mesothelioma: Kinetic-Morphological Dec [PMID:41595142]	Fujita N, Fujita K, Osumi H, Takefuji Y	Cancers	2026
The prognostic impact of CDKN2A/B hemizygous deletions in meningioma. [PMID:41671098]	Ippen FM, Hielscher T, Patel A, Friedel	Neuro Oncol	2026
Cdkn2a/p16Ink4a loss impairs Spatial memory independently of Alzheimer's-associa [PMID:41741874]	Stephan P, Plassard D, Keyes WM, Hérault	Cell Mol Life Sci	2026
Senolytic therapy ameliorates high-fat diet-induced hippocampal senescence and c [PMID:41895394]	Xia X, Yi F, Zhang R, Wu R, Zhang X et a	Exp Neurol	2026
Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared [PMID:39587369]	Angarola BL, Sharma S, Katiyar N	Nat Aging	2025
Analysis of brain and blood single-cell transcriptomics in acute and subacute ph [PMID:38177281]	Garcia-Bonilla L, Shahanoor Z, Sciortino	Nat Immunol	2024
Liver cancer multiomics reveals diverse protein kinase A disruptions convergentl [PMID:39738196]	Requena D, Medico JA, Soto-Ugaldi LF	Nat Commun	2024
A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures. [PMID:37037945]	Govaere O, Hasoon M, Alexander L	Nat Metab	2023
Single-cell profiling reveals transcriptomic signatures of vascular endothelial [PMID:38107519]	Lu Y, Liu X, Zhao J	Front Endocrinol (Lausanne)	2023
A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures. [PMID:37037945]	Govaere O, Hasoon M, Alexander L, Cockel	Nature metabolism	2023
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. [PMID:30290714]	["Araya Jun", "Tsubouchi Kazuya", "Sato	Autophagy	2019
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell [PMID:30936558]	Unknown	Nature neuroscience	2019
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell [PMID:30936558]	Unknown	Nature neuroscience	2019
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. [PMID:30290714]	["Araya Jun", "Tsubouchi Kazuya", "Sato	Autophagy	2019
Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium [PMID:29642012]	["Scala, Federico", "Nenov, Miroslav N",	Cell reports	2018
Fan-Shaped Body Neurons in the Drosophila Brain Regulate Both Innate and Conditi [PMID:30089267]	Hu Wantong; Peng Yiqing; Sun Jiameng; Zh	Cell reports	2018
Tau protein aggregation is associated with cellular senescence in the brain. [PMID:30126037]	["Musi Nicolas", "Valentine Joseph M", "	Aging cell	2018
Tau protein aggregation is associated with cellular senescence in the brain. [PMID:30126037]	["Musi Nicolas", "Valentine Joseph M", "	Aging cell	2018
Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium [PMID:29642012]	["Scala, Federico", "Nenov, Miroslav N",	Cell reports	2018

Debates (15)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning CDKN2A in their description or question text

No additional research found

CDKN2A

Understanding Entity Pages

Summary

Wiki Pages (2)

cdkn2a

CDKN2A Protein

Pathway Diagram

Outgoing (360)

Incoming (98)

Targeting Hypotheses (3)

Mentioning Analyses (8)

Does pericyte senescence drive BBB breakdown or result from neurodegeneration as

Allen Mouse Brain Aging Atlas: cross-age gene expression analysis

What specific gene expression signatures in aging mouse brain predict human AD v

How can senescent microglia be molecularly distinguished from beneficial activat

How do regional, age, and sex-dependent differences in microglial populations af

Senescent cell clearance as neurodegeneration therapy

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Senescent cell clearance as neurodegeneration therapy

Experiments (0)

Related Papers (20)

Debates (15)

Extended debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: SASP Modulation Rather Than Cell Elimination

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Does pericyte senescence drive BBB breakdown or result from neurodegeneration as

How does gene expression change across age groups (young/middle/old) in hippocam

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

While single-cell sequencing reveals microglial heterogeneity across regions, ag

The debate revealed that microglial senescence markers are poorly defined compar

Related Research