gene

GARS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GARS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

Glycyl-tRNA synthetase 1 - essential for protein synthesis, mutations cause Charcot-Marie-Tooth disease type 2D

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🧬 Gene Info

Gene Symbol	GARS1
Aliases	Glycyl-tRNA synthetase 1
Protein Type	Synthetase
Function	The enzymatic reaction proceeds through a two-step mechanism
Ensembl ID	ENSG00000106105
GeneCards	GARS1
Human Protein Atlas	GARS1
N-terminal domain	Involved in dimerization and protein-protein interactions
Catalytic domain	Contains the active site for amino acid activation and tRNA binding
C-terminal domain	Contributes to tRNA recognition and editing function
Editing domain	Prevents mischarging of tRNA with incorrect amino acids (proofreading)
RNA splicing	Associates with spliceosome components
Cell signaling	Modulates MAPK/ERK and PI3K/AKT pathways
Immune regulation	Involved in interferon-responsive gene expression
Angiogenesis	Promotes blood vessel formation through VEGF signaling
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GARS1

gene · 1483 words

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Pathway Diagram

flowchart TD
    N0["GARS1"]
    N1["BDNF"]
    N1 -->|"co expressed with"| N0
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
BDNF	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GARS1 in their description or question text

No additional research found