gene

GCH2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GCH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GCH2 encodes GTP cyclohydrolase II, the rate-limiting enzyme in tetrahydrobiopterin biosynthesis essential for dopamine, norepinephrine, and serotonin synthesis in neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	GCH2
Full Name	GTP Cyclohydrolase II
Protein Type	Hydrolase
Function	is an essential cofactor for aromatic amino acid hydroxylases (tyrosine hydroxylase, tryptophan hydroxylase, phenylalanine hydroxylase) and nitric oxide synthases.
Primary Expression	both dopaminergic cell bodies in the substantia nigra and their terminals in the striatum, ensuring local BH4 production at both sites of dopamine syn
Ensembl ID	ENSG00000163040
GeneCards	GCH2
Human Protein Atlas	GCH2
Transcriptional regulation	GCH2 expression is induced by cytokines, growth factors, and neuronal activity
Allosteric regulation	Product inhibition by BH4 provides feedback control
Post-translational modification	Phosphorylation can modulate enzyme activity
Associated Diseases	Parkinson's disease, Alzheimer's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GCH2 — GTP Cyclohydrolase II

gene · 1448 words

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Pathway Diagram

graph TD
    GCH2["GCH2"]
    neurodegeneration["neurodegeneration"]
    GCH2 -->|"implicated_in"| neurodegeneration
    style GCH2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GCH2 in their description or question text

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