gene

GEMIN6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GEMIN6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GEMIN6 encodes a component of the SMN complex essential for snRNP biogenesis, critical for motor neuron survival and linked to spinal muscular atrophy

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🧬 Gene Info

Gene Symbol	GEMIN6
Full Name	Gem-Associated Protein 6
Chromosome	2p16.3
Function	is a component of the SMN (Survival of Motor Neurons) complex, which is essential for the biogenesis of small nuclear ribonucleoproteins (snRNPs) crucial for pre-mRNA splicing.
Primary Expression	motor neurons, and mutations in SMN1 (the primary SMA-causing gene) lead to spinal muscular atrophy (SMA)
Amino Acids	244 aa
UniProt ID	[Q9Y5B2](https://www.uniprot.org/uniprotkb/Q9Y5B2)
Ensembl ID	ENSG00000179750
OMIM	609651
GeneCards	GEMIN6
Human Protein Atlas	GEMIN6
N-terminal domain	mediates interaction with other Gemin proteins
Central region	contains motifs for protein-protein interactions
C-terminal domain	contributes to SMN complex stability
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GEMIN6 — Gem-Associated Protein 6

gene · 1710 words

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Pathway Diagram

graph TD
    GEMIN6["GEMIN6"]
    neurodegeneration["neurodegeneration"]
    GEMIN6 -->|"implicated_in"| neurodegeneration
    style GEMIN6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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