gene

GEMIN7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GEMIN7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gem-Associated Protein 7, a component of the SMN complex critical for snRNP assembly, pre-mRNA splicing, and neuronal function in neurodegeneration

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🧬 Gene Info

Gene Symbol	GEMIN7
Full Name	Gem-Associated Protein 7
Chromosome	19q13.33
Function	is an integral component of the SMN complex, which performs the following critical functions
Molecular Weight	30 kDa
Amino Acids	258 aa
UniProt ID	[Q9H0C8](https://www.uniprot.org/uniprot/Q9H0C8)
Ensembl ID	ENSG00000180525
OMIM	609652
GeneCards	GEMIN7
Human Protein Atlas	GEMIN7
snRNP Biogenesis	Proper assembly of snRNPs is essential for pre-mRNA splicing[@kashima2008]
Spliceosome Assembly	snRNPs form the spliceosome complex that removes introns from pre-mRNA
Alternative Splicing	Defects in snRNP assembly lead to aberrant alternative splicing patterns
Spliceosome Recycling	Facilitates reassembly after splicing catalysis
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GEMIN7 Gene

gene · 2036 words

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Pathway Diagram

graph TD
    GEMIN7["GEMIN7"]
    neurodegeneration["neurodegeneration"]
    GEMIN7 -->|"implicated_in"| neurodegeneration
    style GEMIN7 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GEMIN7 in their description or question text

No additional research found