concept

GENOMIC INSTABILITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GENOMIC INSTABILITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

1Analyses

7Outgoing

14Incoming

0Experiments

1Debates

No summary available yet.

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💡 Concept Info

Name	GENOMIC INSTABILITY

Pathway Diagram

graph TD
    GENOMIC_INSTABILITY[GENOMIC INSTABILITY]
    GENOMIC_INSTABILITY -->|contributes to| Neurodegenerative_Disease[Neurodegenerative Disease]
    GENOMIC_INSTABILITY -->|involved_in| AGING[AGING]
    GENOMIC_INSTABILITY -->|contributes to| Disease_variability[Disease variability]
    GENOMIC_INSTABILITY -->|contributes to| Aging[Aging]
    GENOMIC_INSTABILITY -->|causes| neurodegenerative_diseases[neurodegenerative diseases]
    TET2[TET2] -.protects against.-> GENOMIC_INSTABILITY
    DNA_Double_Strand_Breaks[DNA Double-Strand Breaks] -->|causes| GENOMIC_INSTABILITY
    R_Loops[R-Loops] -->|contributes to| GENOMIC_INSTABILITY
    NRF2[NRF2] -->|regulates| GENOMIC_INSTABILITY
    Tet2_Loss[Tet2 Loss] -->|contributes to| GENOMIC_INSTABILITY
    CGAS[CGAS] -->|contributes to| GENOMIC_INSTABILITY
    PSME2[PSME2] -->|correlates_with| GENOMIC_INSTABILITY
    mitochondrial_dysfunction[mitochondrial dysfunction] -->|promotes| GENOMIC_INSTABILITY
    autophagy_deficiency[autophagy deficiency] -->|activates| GENOMIC_INSTABILITY

Outgoing (7)

Target	Relation	Type	Str
AGING	involved_in	process	0.85
Neurodegenerative Disease	associated_with	disease	0.85
Disease variability	contributes_to	phenotype	0.80
Aging	contributes_to	phenotype	0.80
Parkinson's Disease	associated_with	disease	0.80
neurodegenerative diseases	associated_with	disease	0.70
neurodegenerative diseases	causes	disease	0.70

Incoming (14)

Source	Relation	Type	Str
TET2	protects_against	entity	0.90
CGAS	associated_with	gene	0.90
DNA Double-Strand Breaks	causes	process	0.90
NAD+ depletion	causes	mechanism	0.90
24198348	generate	paper	0.90
NRF2	regulates	protein	0.85
CGAS	contributes_to	gene	0.85
R-Loops	contributes_to	mechanism	0.85
Tet2 Loss	contributes_to	mechanism	0.85
PSME2	correlates_with	gene	0.85
mitochondrial dysfunction	promotes	process	0.75
Global DNA hypomethylation	causes	mechanism	0.70
autophagy deficiency	activates	process	0.70
29419415	promote	paper	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying epigenetic clocks and biological aging in neu

closed · Rounds: 4 · Score: 0.88 · 2026-04-01

Related Research

Hypotheses and analyses mentioning GENOMIC INSTABILITY in their description or question text

No additional research found