Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Aging: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Aging is a disease characterized by neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Age-Related Diseases, Age-Related Neuropathy, Als. Connected to 3158 entities in the SciDEX knowledge graph.
| Associated Genes | TGM2, LRP8, LRP5, LRP1, LRP2, LRP1B, LRP4, PAH |
| Therapeutic Agents | Indole Derivatives, Xiyangshen Sanqi Danshen Granules, hESC-Exosomes, ABT263, Hesc-Exos |
| KG Connections | 4818 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
subgraph Signaling["Signaling"]
Aging["Aging"] -->|"activates"| Complement["Complement"]
Aging["Aging"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
Aging["Aging"] -->|"activates"| Apoptosis_1["Apoptosis"]
Aging["Aging"] -->|"activates"| Nf__b["Nf-Kappab"]
BDNF["BDNF"] -->|"activates"| Aging["Aging"]
SIRT1["SIRT1"] -->|"regulates"| Aging["Aging"]
TNF["TNF"] -->|"activates"| Aging["Aging"]
end
subgraph Therapeutic["Therapeutic"]
Aging["Aging"] -->|"therapeutic target"| Apoptosis["Apoptosis"]
Aging["Aging"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
Aging["Aging"] -->|"therapeutic target"| Autophagy["Autophagy"]
Aging["Aging"] -->|"therapeutic target"| Mtor["Mtor"]
MTOR["MTOR"] -->|"therapeutic target"| Aging["Aging"]
OVERVIEW_2["OVERVIEW"] -->|"therapeutic target"| Aging["Aging"]
end
subgraph Pathology["Pathology"]
Aging["Aging"] -->|"associated with"| Immune_Response["Immune Response"]
OVERVIEW["OVERVIEW"] -->|"associated with"| Aging["Aging"]
end
style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Complement fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Apoptosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Apoptosis_1 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Nf__b fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Blood_Brain_Barrier fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Immune_Response fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MTOR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style BDNF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OVERVIEW fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style SIRT1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OVERVIEW_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TNF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Complement | activates | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Immune Response | associated_with | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| Nf-Κb | therapeutic_target | pathway | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Epigenetic | associated_with | pathway | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Neuroinflammation | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Epigenetic | regulates | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| Inflammasome | activates | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Mitochondrial Function | therapeutic_target | pathway | 1.00 |
| Epigenetic | activates | pathway | 1.00 |
| Immune Response | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | inhibits | pathway | 1.00 |
| Mtor | regulates | pathway | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| Senescence | inhibits | pathway | 1.00 |
| Senescence | regulates | pathway | 1.00 |
| Glycolysis | activates | pathway | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| Oxidative Stress | causes | pathway | 1.00 |
| Senescence | activates | pathway | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Als | biomarker_for | disease | 1.00 |
| Longevity | associated_with | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Inflammation | implicated_in | disease | 1.00 |
| Neurodegeneration | causes | disease | 1.00 |
| Apoptosis | implicated_in | pathway | 1.00 |
| Als | implicated_in | disease | 1.00 |
| Als | contributes_to | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | therapeutic_target | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| OVERVIEW | associated_with | gene | 1.00 |
| SIRT1 | regulates | gene | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| PARKIN | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| APOE | associated_with | gene | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| DNA | activates | gene | 1.00 |
| DNA | regulates | gene | 1.00 |
| Stroke | associated_with | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| DNA | associated_with | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| DNA | inhibits | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| AMPK | therapeutic_target | gene | 1.00 |
| GENES | expressed_in | gene | 1.00 |
| TP53 | therapeutic_target | gene | 1.00 |
| NRF2 | therapeutic_target | gene | 1.00 |
| GAL | activates | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| STAT3 | activates | gene | 1.00 |
| MIRNAS | therapeutic_target | gene | 1.00 |
| P53 | therapeutic_target | gene | 1.00 |
| GFAP | biomarker_for | gene | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| MTOR | regulates | gene | 1.00 |
| APOE4 | associated_with | gene | 1.00 |
| TNF | associated_with | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| MICROGLIA | associated_with | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop tACS targeting entorhinal cortex layer II SST in | 0.625 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging | 0.587 | neurodegeneration | Gene expression changes in aging mouse b |
| TNFRSF25-Mediated Aging Exosome Pathway Inhibition | 0.412 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674
neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.514
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578
neurodegeneration | 2026-04-14 | 0 hypotheses
neurodegeneration | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Death receptor 3: A paradoxical biomarker and therapeutic target in pan-cancer. [PMID:41605339] | Fang W, Du J, Xu Z, Liu Q, Liu Y et al. | Crit Rev Oncol Hematol | 2026 | 0 |
| Homocysteine as a biomarker in arthritis and depression: Evidence from NHANES an [PMID:41693749] | Deng C, He Z, Zhu X | SAGE Open Med | 2026 | 0 |
| The involvement of TNFRSF25 in age-related hearing loss. [PMID:41882185] | Roche MV, Tang PC, Yan D, De Marchena MR | Hum Genet | 2026 | 0 |
| Maternal immune activation perturbs intestinal niche through microbial glyceroph [PMID:41926285] | Chang H, Zhu X, Shen C, Xu X, Ni Y et al | Cell Rep | 2026 | 0 |
| Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404] | Qi C, Sima W, Mao H, Hu E, Ge J et al. | Nat Commun | 2025 | 0 |
| Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329] | Morabito A, Zerlaut Y, Dhanasobhon D, Be | Neuron | 2025 | 0 |
| Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373] | Fisher J, Verhagen M, Long Z, Moissidis | Neuron | 2024 | 0 |
| Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473] | Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a | Adv Sci (Weinh) | 2024 | 0 |
| Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981] | Almeida VN | Ageing Res Rev | 2024 | 0 |
| Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213] | Mòdol L, Moissidis M, Selten M, Oozeer F | Neuron | 2024 | 0 |
| De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258] | Tang S, Conte V, Zhang DJ, Žedaveinytė R | Science | 2024 | 0 |
| Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868] | Xia D, Lianoglou S, Sandmann T, Calvert | Mol Neurodegener | 2022 | 0 |
| Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapi [PMID:33070149] | Fogaça MV, Wu M, Li C, Li XY, Picciotto | Mol Psychiatry | 2021 | 0 |
| Identification of Faecalibacterium prausnitzii strains for gut microbiome-based [PMID:34622235] | Ueda A, Shinkai S, Shiroma H, Taniguchi | Cell Rep Med | 2021 | 0 |
| Somatostatin, Olfaction, and Neurodegeneration. [PMID:32140092] | Saiz-Sanchez D, Ubeda-Bañon I, Flores-Cu | Front Neurosci | 2020 | 0 |
| Somatostatin replacement: a new strategy for treating diabetic retinopathy. [PMID:23745546] | Hernández C, Simó R, European Consortium | Curr Med Chem | 2013 | 0 |