Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AGING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
AGING is a phenotype associated with neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with AGE_RELATED_DISEASES, ALS, ALZHEIMER. Connected to 2696 entities in the SciDEX knowledge graph.
Knowledge base pages for this entity
graph TD
subgraph Pathology["Pathology"]
AGING["AGING"] -->|"associated with"| MICROGLIA["MICROGLIA"]
AGING["AGING"] -->|"associated with"| Aging["Aging"]
AGING["AGING"] -->|"associated with"| Alzheimer["Alzheimer"]
AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| AGING["AGING"]
INFLAMMATION["INFLAMMATION"] -->|"associated with"| AGING["AGING"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"causes"| AGING["AGING"]
ALZHEIMER["ALZHEIMER"] -->|"causes"| AGING["AGING"]
end
subgraph Signaling["Signaling"]
AGING["AGING"] -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
AGING["AGING"] -->|"activates"| Diabetes["Diabetes"]
AGING["AGING"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
AGING["AGING"] -->|"activates"| Inflammation["Inflammation"]
AGING["AGING"] -->|"activates"| Autophagy["Autophagy"]
AGING["AGING"] -->|"regulates"| Aging_1["Aging"]
AUTOPHAGY_2["AUTOPHAGY"] -->|"regulates"| AGING["AGING"]
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"activates"| AGING["AGING"]
end
style AGING fill:#5d4400,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEUROINFLAMMATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Diabetes fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Neuroinflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Aging_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY_2 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style INFLAMMATION fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOCHONDRIAL_DYSFUNCTION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| MICROGLIA | associated_with | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Diabetes | activates | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Aging | regulates | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Cardiovascular | therapeutic_target | disease | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Senescence | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Aging | inhibits | disease | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Aging | interacts_with | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 1.00 |
| Aging | contributes_to | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Parkinson | therapeutic_target | disease | 1.00 |
| Mitochondrial Function | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Aging | protects_against | disease | 1.00 |
| APOE | associated_with | gene | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| Diabetes | therapeutic_target | disease | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Senescence | regulates | disease | 1.00 |
| NEUROINFLAMMATION | regulates | gene | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | associated_with | pathway | 1.00 |
| AUTOPHAGY | regulates | pathway | 1.00 |
| INFLAMMATION | associated_with | phenotype | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | causes | gene | 1.00 |
| ALZHEIMER | causes | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| NAD | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 1.00 |
| ALZHEIMER | regulates | gene | 1.00 |
| STROKE | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| NEURODEGENERATION | causes | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| ALZHEIMER'S DISEASE | regulates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | regulates | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| OXIDATIVE STRESS | causes | gene | 1.00 |
| MITOPHAGY | regulates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| AMYLOID | activates | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| ALZHEIMER | therapeutic_target | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop tACS targeting entorhinal cortex layer II SST in | 0.625 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging | 0.587 | neurodegeneration | Gene expression changes in aging mouse b |
| TNFRSF25-Mediated Aging Exosome Pathway Inhibition | 0.412 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
epigenetics | 2026-04-15 | 0 hypotheses
neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674
neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.514
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578
neurodegeneration | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Death receptor 3: A paradoxical biomarker and therapeutic target in pan-cancer. [PMID:41605339] | Fang W, Du J, Xu Z, Liu Q, Liu Y et al. | Crit Rev Oncol Hematol | 2026 | 0 |
| Homocysteine as a biomarker in arthritis and depression: Evidence from NHANES an [PMID:41693749] | Deng C, He Z, Zhu X | SAGE Open Med | 2026 | 0 |
| The involvement of TNFRSF25 in age-related hearing loss. [PMID:41882185] | Roche MV, Tang PC, Yan D, De Marchena MR | Hum Genet | 2026 | 0 |
| Maternal immune activation perturbs intestinal niche through microbial glyceroph [PMID:41926285] | Chang H, Zhu X, Shen C, Xu X, Ni Y et al | Cell Rep | 2026 | 0 |
| Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404] | Qi C, Sima W, Mao H, Hu E, Ge J et al. | Nat Commun | 2025 | 0 |
| Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329] | Morabito A, Zerlaut Y, Dhanasobhon D, Be | Neuron | 2025 | 0 |
| Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373] | Fisher J, Verhagen M, Long Z, Moissidis | Neuron | 2024 | 0 |
| Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473] | Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a | Adv Sci (Weinh) | 2024 | 0 |
| Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981] | Almeida VN | Ageing Res Rev | 2024 | 0 |
| Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213] | Mòdol L, Moissidis M, Selten M, Oozeer F | Neuron | 2024 | 0 |
| De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258] | Tang S, Conte V, Zhang DJ, Žedaveinytė R | Science | 2024 | 0 |
| Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868] | Xia D, Lianoglou S, Sandmann T, Calvert | Mol Neurodegener | 2022 | 0 |
| Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapi [PMID:33070149] | Fogaça MV, Wu M, Li C, Li XY, Picciotto | Mol Psychiatry | 2021 | 0 |
| Identification of Faecalibacterium prausnitzii strains for gut microbiome-based [PMID:34622235] | Ueda A, Shinkai S, Shiroma H, Taniguchi | Cell Rep Med | 2021 | 0 |
| Somatostatin, Olfaction, and Neurodegeneration. [PMID:32140092] | Saiz-Sanchez D, Ubeda-Bañon I, Flores-Cu | Front Neurosci | 2020 | 0 |
| Somatostatin replacement: a new strategy for treating diabetic retinopathy. [PMID:23745546] | Hernández C, Simó R, European Consortium | Curr Med Chem | 2013 | 0 |