Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GNB2 |
| Full Name | G Protein Subunit Beta 2 |
| Chromosome | 7q22.1 |
| Function | Receptor activation: An extracellular ligand activates a GPCR at the plasma membrane |
| Primary Expression | Brain (cortex, hippocampus, cerebellum), Heart, Liver, Immune cells |
| Molecular Weight | 37 kDa |
| Amino Acids | 340 aa |
| Pathways | PI3K, PI3K signaling, MAPK, MAPK signaling |
| UniProt ID | P62879 |
| NCBI Gene ID | 2783 |
| Ensembl ID | ENSG00000186470 |
| OMIM | 139311 |
| GeneCards | GNB2 |
| Human Protein Atlas | GNB2 |
| Protein | GNB2 Protein |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GNB2["GNB2"]
neurodegeneration["neurodegeneration"]
GNB2 -->|"implicated_in"| neurodegeneration
style GNB2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||