entity

GPR41

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPR41: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

1Hypotheses

5Analyses

7Outgoing

4Incoming

0Experiments

6Debates

No AI portrait yet

Outgoing (7)

Target	Relation	Type	Str
h-6aebb76ee3	targeted_by	hypothesis	1.00
microglial clearance of alpha-synuclein	modulates	process	0.70
microglial anti-inflammatory responses	regulates	phenotype	0.70
microglial_quiescence	maintains	phenotype	0.70
DRP1	regulates	protein	0.70
neuroprotective_signaling	activates	pathway	0.70
astrocyte metabolic reprogramming	regulates	process	0.50

Incoming (4)

Source	Relation	Type	Str
h-6aebb76ee3	targets	hypothesis	1.00
butyrate	activates	metabolite	0.70
SCFA	activates	gene	0.70
H1	associated_with	hypothesis	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Dissociating SCFA's Dual Signaling Through GPR43/GPR41 Biase	0.670	neurodegeneration	Do SCFAs directly modulate α-synuclein a

Mentioning Analyses (5)

Scientific analyses that reference this entity

How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegen

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.728

How does engineered C. butyricum cross the blood-brain barrier to directly bind

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.699

Does reduced Prevotellaceae abundance cause PD pathology or result from it?

neurodegeneration | 2026-04-11 | 7 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 7 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (6)

Multi-agent debates referencing this entity

Debate: SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysreg

closed · Rounds: 4 · Score: 0.13 · 2026-04-27

How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegen

closed · Rounds: 4 · Score: 0.76 · 2026-04-26

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

closed · Rounds: 4 · Score: 0.82 · 2026-04-22

The abstract claims C. butyricum-GLP-1 crosses the BBB and binds to GLP-1 recept

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Does reduced Prevotellaceae abundance cause PD pathology or result from it?

closed · Rounds: 4 · Score: 0.95 · 2026-04-11

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning GPR41 in their description or question text

No additional research found