concept

BUTYRATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BUTYRATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

24Outgoing

7Incoming

0Experiments

0Debates

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💡 Concept Info

Name	BUTYRATE

Pathway Diagram

graph TD
    BUTYRATE["BUTYRATE"]
    BUTYRATE -->|"activates"| Intestinal_Epithelial_Cells["Intestinal Epithelial Cells"]
    BUTYRATE -->|"inhibits"| HISTONE_DEACETYLASE["HISTONE DEACETYLASE"]
    BUTYRATE -->|"inhibits"| HDAC["HDAC"]
    BUTYRATE -->|"maintains"| INTESTINAL_BARRIER["INTESTINAL_BARRIER"]
    BUTYRATE -->|"produced_by"| FAECALIBACTERIUM["FAECALIBACTERIUM"]
    BUTYRATE -.protects against.-> Blood_Brain_Barrier_Integrity["Blood-Brain Barrier Integrity"]
    BUTYRATE -->|"involved_in"| Gut_Brain_Communication["Gut-Brain Communication"]

Outgoing (24)

Target	Relation	Type	Str
HISTONE DEACETYLASE	inhibits	enzyme	0.95
Cognitive Impairment	treats	phenotype	0.95
Intestinal Epithelial Cells	activates	cell_type	0.95
Quinolinic Acid-Induced Cognitive Decline	protects_against	phenotype	0.90
BDNF	upregulates	protein	0.90
Intestinal Epithelial Cells	associated_with	cell_type	0.90
Tight Junction Protein Formation	associated_with	process	0.90
Multiorgan Dysfunction	treats	phenotype	0.90
Histone Acylation	modulates	process	0.85
Lifespan	associated_with	phenotype	0.85
Blood-Brain Barrier Integrity	protects_against	phenotype	0.85
Gut-Brain Communication	involved_in	pathway	0.85
H3K18Ac	upregulates	biomarker	0.85
Intestinal Epithelial Cell	expressed_in	cell_type	0.85
Intestinal Epithelial Cells	expressed_in	cell_type	0.80
Brain Trauma Recovery	treats	phenotype	0.80
Brain Trauma Recovery	associated_with	phenotype	0.80
Intestinal Barrier Disruption	treats	phenotype	0.80
Neurodegeneration	protects_against	phenotype	0.80
gut barrier integrity	associated_with	phenotype	0.75
Dementia	treats	disease	0.75
cognitive impairment	protects_against	process	0.70
BDNF	activates	protein	0.70
Brain Trauma	associated_with	disease	0.70

Incoming (7)

Source	Relation	Type	Str
Gut Dysbiosis	associated_with	phenotype	0.90
Tributyrin	associated_with	drug	0.90
Microbiota	associated_with	cell_type	0.90
Herba Patriniae With Probiotics	upregulates	drug	0.85
Intestinal Barrier Disruption	associated_with	phenotype	0.85
Gut Dysbiosis	downregulates	phenotype	0.80
Faecalibacterium prausnitzii	promotes	drug	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity