Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCFA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Bifidobacterium | associated_with | cell_type | 0.80 |
| Hypertension | associated_with | disease | 0.80 |
| Obesity | protects_against | disease | 0.78 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism | 0.537 | neurodegeneration | Do SCFAs directly modulate α-synuclein a |
| Dissociating SCFA's Dual Signaling Through GPR43/GPR41 Biase | 0.525 | neurodegeneration | Do SCFAs directly modulate α-synuclein a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.537
pharmacokinetics | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Bacteroides coprocola protects dopaminergic neurons in rotenone-induced Parkinso [PMID:41761283] | Liu Z, Nie J, Li Y, Huang M, Chen Z et a | Transl Neurodegener | 2026 | 0 |
| Salidroside ameliorates diabetic amyotrophy by targeting Caspase-3 to inhibit ap [PMID:40715275] | Wang H, Yousaf W, Haseeb A, Wang Z, Zhen | Sci Rep | 2025 | 0 |
| Gut Microbiota-Derived Lipopolysaccharides and Short-Chain Fatty Acids Regulate [PMID:41031863] | Maruyama D, Doan TNM, Tian X, Chaki T, Y | Ann N Y Acad Sci | 2025 | 0 |
| Effect of Calebin-A on Critical Genes Related to NAFLD: A Protein-Protein Intera [PMID:38751599] | Mahmoudi A, Hajihasani MM, Majeed M, Jam | Curr Genomics | 2024 | 0 |
| HDAC6 as a Prognostic Factor and Druggable Target in HER2-Positive Breast Cancer [PMID:39594707] | Cortesi M, Bravaccini S, Ravaioli S, Pet | Cancers (Basel) | 2024 | 0 |
| Acute heat stress reduces viability but increases lactate secretion of porcine i [PMID:34392171] | Yang CX, Chen L, Yang YW, Mou Q, Du ZQ | Theriogenology | 2021 | 0 |
| Lychee (Litchi chinensis Sonn.) Pulp Phenolics Activate the Short-Chain Fatty Ac [PMID:33533603] | Huang G, Wang Z, Wu G, Zhang R, Dong L e | J Agric Food Chem | 2021 | 0 |