gene

GRIK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GRIK2 encodes the GluK2 kainate receptor subunit, involved in synaptic transmission, plasticity, and neurodegeneration. Associated with ASD, intellectual disability, and ALS.

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🧬 Gene Info

Gene Symbol	GRIK2
Chromosome	6q16.3
Protein Type	Receptor
Function	is a member of the kainate family of ionotropic glutamate receptors.
Molecular Weight	100 kDa
Amino Acids	906 aa
Ensembl ID	ENSG00000164418
GeneCards	GRIK2
Human Protein Atlas	GRIK2
Homomeric receptors	GluK2/GluK2/GluK2/GluK2
Heteromeric receptors	Co-assembly with GluK1, GluK3, GluK4, or GluK5
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

grik2

protein · 1855 words

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GRIK2 Gene

gene · 1776 words

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Pathway Diagram

graph TD
    GRIK2["GRIK2"]
    neurodegeneration["neurodegeneration"]
    GRIK2 -->|"implicated_in"| neurodegeneration
    style GRIK2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRIK2 in their description or question text

No additional research found