protein

GRM1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRM1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Grm1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	GRM1PROTEIN
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	** \| Cell membrane, postsynaptic density \|
Molecular Weight	150 kDa
GeneCards	GRM1PROTEIN
Human Protein Atlas	GRM1PROTEIN
Venus flytrap domain (VFT)	Binds glutamate and other agonists
Cysteine-rich domain (CRD)	Links VFT to transmembrane domain
Dimerization interface	Forms functional homodimers or heterodimers with GRM5
Seven transmembrane helices (7TM)	Typical GPCR structure
Conserved motifs	For G protein coupling
Allosteric binding sites	For positive and negative allosteric modulators
C-terminal tail	Contains PDZ-binding motifs and phosphorylation sites
G protein coupling domain	Activates Gq/11 proteins
Associated Diseases	neurodegeneration
Interactions	MTOR
KG Connections	8 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

grm1 Protein

protein · 909 words

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Pathway Diagram

graph TD
    GRM1PROTEIN["GRM1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GRM1PROTEIN -->|"implicated_in"| neurodegeneration
    style GRM1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRM1PROTEIN in their description or question text

No additional research found