Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GluN2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| thalamic burst firing | regulates | phenotype | 0.90 |
| Antidepressant Response | involved_in | phenotype | 0.85 |
| CaMKII | activates | protein | 0.70 |
| PINK1-PARK2-mediated mitophagy | regulates | process | 0.70 |
| PINK1 | activates | gene | 0.70 |
| cortical slow-wave oscillations | associated_with | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neuroscience | 2026-04-28 | 7 hypotheses Top: 0.808
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Neuropathology of incidental Lewy body & prodromal Parkinson's disease. [PMID:37173733] | Koeglsperger T, Rumpf SL, Schließer P, S | Molecular neurodegeneration | 2023 | 0 |
| Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurod [PMID:33603230] | Dong Y, D'Mello C, Pinsky W, Lozinski BM | Nature neuroscience | 2021 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning GluN2B in their description or question text
Score: 0.565 · neuroscience · 2026-04-20
## Mechanistic Overview GluN2B-Mediated Microglial Activation and Tau Propagation starts from the claim that modulating
Score: 0.556 · neuroscience · 2026-04-28
Thalamocortical circuits interface with para-arterial glymphatic influx pathways while corticopial projections interface
Score: 0.543 · neuroscience · 2026-04-21
## Mechanistic Overview TREM2-GluN2B Circuit: Microglial Control of Thalamocortical Oscillations and Glymphatic Tau Clea
Score: 0.526 · neuroscience · 2026-04-28
Postnatal thalamic development exhibits delayed GluN2B expression in males, causing prolonged critical period vulnerabil
Score: 0.491 · neuroscience · 2026-04-21
## Mechanistic Overview GluN2B-Regulated Microglial Phagocytosis of Tau Aggregates via CX3CR1 Signaling starts from the
Score: 0.485 · neuroscience · 2026-04-21
## Mechanistic Overview GluN2B-Mediated Perivascular Pericyte Control of Glymphatic Tau Clearance starts from the claim
Score: 0.380 · neuroscience · 2026-04-27
This hypothesis proposes that GluN2B-containing NMDA receptors on microglia directly regulate tau protein clearance thro