protein 769 words KG: NR2B
Contents

NR2B (GluN2B) NMDA Receptor Subunit

🔬 Protein Info
Gene SymbolNR2B
Full NameNR2B (GluN2B)
AliasesGluN2B
Protein FamilyIonotropic glutamate receptor (NMDA) family
Protein TypeReceptor
FunctionNR2B (GRIN2B) is a subunit of the NMDA glutamate receptor that modulates synaptic plasticity, learning, and memory
Primary Expressionthe forebrain, where they mediate long-term potentiation
Subcellular LocalizationPostsynaptic density,
Molecular Weight180 kDa
PathwaysEpigenetic
UniProt IDQ13691
GeneCardsNR2B
Human Protein AtlasNR2B
Associated Diseasesexcitotoxicity
InteractionsABETA, CDK5
KG Connections15 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (4)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

See Also (10)

NeuRon Therapeutics
company · KG edge: expressed_in
Neurodegeneration
disease · KG edge: implicated_in
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates
Genes
index · KG edge: regulates
DLG4 Gene - PSD-95
gene · KG edge: regulates

Knowledge Graph (12 edges)

NR2B regulates PSD95
NR2B regulates FOS
NR2B regulates NPAS4
NR2B regulates DLG4
NR2B regulates GRIN2B
NPAS4 regulates NR2B
DLG4 regulates NR2B
GENES regulates NR2B
NR2B regulates C-FOS
NR2B activates ALS

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