Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PINK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PINK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with AD, ALI, ALS. Connected to 1749 entities in the SciDEX knowledge graph.
| Gene Symbol | PINK1 |
| Full Name | Deficient Dopamine Neurons |
| Chromosome | 1p36.12 |
| Protein Family | Serine/threonine kinase family |
| Protein Type | Kinase |
| Function | is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021]. |
| Primary Expression | Mitochondrial outer membrane |
| Molecular Weight | 63 kDa |
| Pathways | Amyloid, Apoptosis, Autophagy, Chaperone, Cholesterol |
| UniProt ID | Q9BXM7 |
| NCBI Gene ID | 65018 |
| Ensembl ID | ENSG00000158828 |
| OMIM | 608309 |
| GeneCards | PINK1 |
| Human Protein Atlas | PINK1 |
| Associated Diseases | AD, ALI, ALS, APOPTOSIS, Aging |
| Known Drugs/Compounds | DEFERIPRONE, RAPAMYCIN, MELATONIN, propionic acid, Ligustilide, BGP-15 |
| Interactions | BCL2L13, NLRP3, ABCD3, FIP200, RTN3, SESN2 |
| KG Connections | 3597 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PINK1["PINK1"] -->|"causes"| PD["PD"]
PINK1["PINK1"] -->|"phosphorylates"| UBIQUITIN["UBIQUITIN"]
PINK1["PINK1"] -->|"activates"| PARKIN["PARKIN"]
PINK1["PINK1"] -->|"activates"| MITOPHAGY["MITOPHAGY"]
PINK1["PINK1"] -->|"recruits"| NDP52["NDP52"]
PINK1["PINK1"] -->|"recruits"| OPTINEURIN["OPTINEURIN"]
propionic_acid["propionic acid"] -->|"activates"| PINK1["PINK1"]
CAT["CAT"] -->|"interacts"| PINK1["PINK1"]
OPTN["OPTN"] -->|"interacts"| PINK1["PINK1"]
DNM1L["DNM1L"] -->|"interacts"| PINK1["PINK1"]
style PINK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| PARKIN | activates | protein | 1.00 |
| MTOR | activates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| PRKN | activates | gene | 1.00 |
| PARKIN | regulates | protein | 1.00 |
| P62 | activates | gene | 1.00 |
| PARKIN | associated_with | gene | 1.00 |
| PARKIN | inhibits | gene | 1.00 |
| UBIQUITIN | regulates | gene | 1.00 |
| MITOPHAGY | activates | pathway | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Als | regulates | disease | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Mitochondrial Function | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Cancer | activates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Parkinson | regulates | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| AMPK | activates | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Mitophagy | inhibits | pathway | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| MITOCHONDRIA | regulates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| MTDNA | activates | gene | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PARKIN | regulates | gene | 1.00 |
| PARKIN | activates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| PARKIN | associated_with | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| MITOPHAGY | associated_with | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | disease | 1.00 |
| MITOPHAGY | regulates | gene | 0.98 |
| MTK458 | activates | drug | 0.95 |
| PHB2 | associated_with | protein | 0.95 |
| SRT2104 | upregulates | drug | 0.92 |
| MAPK pathway inhibition | contributes_to | drug | 0.90 |
| MYC | activates | gene | 0.90 |
| PARK2 | phosphorylates | gene | 0.90 |
| Spautin-1 | associated_with | compound | 0.90 |
| PARL | cleaves | protein | 0.90 |
| Mitochondrial Import Pathway | associated_with | process | 0.90 |
| ATAD3A | inhibits | protein | 0.90 |
| SIRT3 | deacetylates | protein | 0.90 |
| Mitochondrial Import Pathway Blockade | activates | mechanism | 0.90 |
| SPAUTIN-1 | stabilizes | compound | 0.90 |
| MIF | inhibits | protein | 0.90 |
| Mitochondrial membrane potential loss | activates | mechanism | 0.90 |
| DIZE | upregulates | drug | 0.90 |
| mitochondrial membrane potential loss | activates | phenotype | 0.90 |
| TOM | binds | protein | 0.90 |
| AMYLOID | associated_with | gene | 0.90 |
| APOPTOSIS | associated_with | gene | 0.90 |
| PSMD14 | activates | protein | 0.90 |
| P53 | represses | protein | 0.90 |
| TIM23 | interacts_with | protein | 0.90 |
| h-a11f71b5 | targets_gene | hypothesis | 0.90 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.90 |
| icaritin | activates | drug | 0.88 |
| mitochondrial damage | activates | phenotype | 0.88 |
| Nrf2 | upstream_of | gene | 0.85 |
| Gastrodin | activates | drug | 0.85 |
| Lycopene | modulates | drug | 0.85 |
| RAB7A | interacts_with | protein | 0.85 |
| Hesperetin | upregulates | compound | 0.85 |
| TIMM23 complex disruption | activates | mechanism | 0.85 |
| BAP31 | interacts_with | protein | 0.85 |
| SIRT1 | upregulates | protein | 0.85 |
| FOXO3 | upregulates | gene | 0.85 |
| CRISPR-Cas9 | targets | process | 0.85 |
| isoginkgetin | associated_with | compound | 0.85 |
| APOE | inhibits | gene | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK | 0.509 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor | 0.418 | neurodegeneration | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.570
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditor [PMID:41593189] | ["Cho S", "Jo E", "Jang H"] | Scientific reports | 2026 | 0 |
| Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730] | Zhang Y, Jiang H, Zhang F, Liao J | Neural regeneration research | 2026 | 0 |
| The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859] | Qi L, Yi J, Shen Y, Jiang H, Yao X et al | Biochem Pharmacol | 2026 | 0 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency [PMID:41832996] | Zhang HH, Zhang ZL, Xu W | Reproduction | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactyl [PMID:41946672] | Jiang F, Huang H, Dong Z, Zhang L, Zhang | Cell Death Discov | 2026 | 0 |
| Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepati [PMID:41965824] | Zhang T, Hu L, Chen D, Chen Y, Zhou F et | Nat Commun | 2026 | 0 |
| α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317] | Wu C, Jiang J, Qiu H, Xie J, Li S | Fish Shellfish Immunol | 2026 | 0 |
| Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899] | Fang Y, Deng M, Huang K, Song H, Chu Y, | Cell communication and signali | 2026 | 0 |
| Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653] | Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y | Journal of diabetes | 2026 | 0 |
| Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101] | Cheng YL, Su MS, Liao CC, Chang TW, Hsie | Journal of microbiology, immun | 2026 | 0 |
| Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436] | Shan C, Szili-Torok T, Yue G, Zhang L, M | Phytomedicine : international | 2026 | 0 |
| Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550] | ["Gao L", "Shen J", "Gao J", "Li T", "Ya | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Comprehensive Insights Into Mitophagy: Mechanisms, Disease Associations, and The [PMID:40714832] | ["Tang M", "Outissint I", "Chen Y", "Gon | Journal of cellular biochemist | 2025 | 0 |
| Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627] | El-Mahrouk SR, El-Kadi AOS | Archives of toxicology | 2025 | 0 |
| Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796] | Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu | Journal of neuroinflammation | 2025 | 0 |
| Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261] | Yang R, Meng X, Zhao W, Xu SQ, Wang SY, | Bioorganic chemistry | 2025 | 0 |
| Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458] | Pradeepkiran JA, Kshirsagar S, Alvir RV, | Biochimica et biophysica acta. | 2025 | 0 |