gene

PINK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PINK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3558Connections

18Hypotheses

10Analyses

50Outgoing

50Incoming

2Experiments

17Debates

Summary

PINK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with AD, ALI, ALS. Connected to 1749 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PINK1
Chromosome	1p36.12
Protein Family	Serine/threonine kinase family
Protein Type	Kinase
Function	is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021].
Primary Expression	Mitochondrial outer membrane
Subcellular Localization	</th><td>Mitochondrial inner membrane (OMM upon activation)</td></tr>
Molecular Weight	63 kDa
Pathways	Amyloid, Apoptosis, Autophagy, Chaperone, Cholesterol
UniProt ID	Q9BXM7
NCBI Gene ID	65018
Ensembl ID	ENSG00000158828
OMIM	608309
GeneCards	PINK1
Human Protein Atlas	PINK1
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	BGP-15, Canagliflozin, CANAGLIFLOZIN, DEFERIPRONE, dimethyl fumarate, Gastrodin
Interactions	ABCD3, ABP, ACHE, Actin, AD, AGING
SciDEX Hypotheses	Dose-Response Framework: PINK1/Parkin Mitophagy as Mitophagy collapse via PINK1-PRKN is the primary a PINK1/PARK2-Mediated Mitophagy Enhancement for Neu (+5 more)
KG Connections	3557 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — PINK1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

6EQI — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q9BXM7 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PINK1["PINK1"] -->|"causes"| PD["PD"]
    PINK1["PINK1"] -->|"phosphorylates"| UBIQUITIN["UBIQUITIN"]
    PINK1["PINK1"] -->|"activates"| PARKIN["PARKIN"]
    PINK1["PINK1"] -->|"activates"| MITOPHAGY["MITOPHAGY"]
    PINK1["PINK1"] -->|"recruits"| NDP52["NDP52"]
    PINK1["PINK1"] -->|"recruits"| OPTINEURIN["OPTINEURIN"]
    propionic_acid["propionic acid"] -->|"activates"| PINK1["PINK1"]
    CAT["CAT"] -->|"interacts"| PINK1["PINK1"]
    OPTN["OPTN"] -->|"interacts"| PINK1["PINK1"]
    DNM1L["DNM1L"] -->|"interacts"| PINK1["PINK1"]
    style PINK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1951)

Target	Relation	Type	Str
ALZHEIMER	activates	gene	1.00
Parkinson	causes	disease	1.00
Alzheimer	activates	disease	1.00
MITOCHONDRIA	regulates	gene	1.00
ROS	activates	gene	1.00
CANCER	activates	gene	1.00
Inflammation	activates	disease	1.00
Mitochondrial Function	activates	pathway	1.00
PARKINSON'S DISEASE	activates	gene	1.00
PARKINSON	activates	gene	1.00
MTDNA	activates	gene	1.00
MITOPHAGY	inhibits	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
Neurodegeneration	activates	disease	1.00
Apoptosis	activates	pathway	1.00
Als	regulates	disease	1.00
Oxidative Stress	activates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
MITOCHONDRIA	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
Cancer	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
GENES	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Parkinson	activates	disease	1.00
APOPTOSIS	activates	gene	1.00
UBIQUITIN	regulates	gene	1.00
AMPK	activates	gene	1.00
Parkinson	regulates	disease	1.00
PRKN	activates	gene	1.00
PARKIN	activates	protein	1.00
PARKIN	inhibits	gene	1.00
MITOPHAGY	activates	pathway	1.00
Als	activates	disease	1.00
Autophagy	activates	pathway	1.00
Mitophagy	regulates	pathway	1.00
Autophagy	regulates	pathway	1.00
Mitophagy	inhibits	pathway	1.00
AUTOPHAGY	regulates	gene	1.00
Tumor	activates	disease	1.00
PARKIN	regulates	protein	1.00
MTOR	activates	gene	1.00
P62	activates	gene	1.00
Mitophagy	activates	pathway	1.00
Aging	activates	disease	1.00
PTEN	activates	gene	1.00
Neuroinflammation	activates	disease	1.00
PARKIN	associated_with	gene	1.00
Mtor	activates	pathway	1.00

Incoming (1607)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
AUTOPHAGY	associated_with	gene	1.00
PARKIN	associated_with	gene	1.00
PARKIN	regulates	gene	1.00
MITOPHAGY	activates	gene	1.00
PTEN	activates	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
PARKIN	activates	gene	1.00
MITOPHAGY	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
MITOPHAGY	regulates	gene	0.98
PHB2	associated_with	protein	0.95
MTK458	activates	drug	0.95
SRT2104	upregulates	drug	0.92
Mitochondrial Import Pathway	associated_with	process	0.90
P53	represses	protein	0.90
Spautin-1	associated_with	compound	0.90
Mitochondrial membrane potential loss	activates	mechanism	0.90
TIM23	interacts_with	protein	0.90
APOPTOSIS	associated_with	gene	0.90
h-a11f71b5	targets	hypothesis	0.90
MIF	inhibits	protein	0.90
PARK2	phosphorylates	gene	0.90
SIRT3	deacetylates	protein	0.90
TOM	binds	protein	0.90
ATAD3A	inhibits	protein	0.90
AMYLOID	associated_with	gene	0.90
SPAUTIN-1	stabilizes	compound	0.90
MAPK pathway inhibition	contributes_to	drug	0.90
PSMD14	activates	protein	0.90
MYC	activates	gene	0.90
PARL	associated_with	protein	0.90
mitochondrial membrane potential loss	activates	phenotype	0.90
Mitochondrial Import Pathway Blockade	activates	mechanism	0.90
DIZE	upregulates	drug	0.90
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.90
icaritin	activates	drug	0.88
mitochondrial damage	activates	phenotype	0.88
Nrf2	upstream_of	gene	0.85
Gastrodin	activates	drug	0.85
CKLF	upregulates	protein	0.85
isoginkgetin	associated_with	compound	0.85
APOE	inhibits	gene	0.85
FOXO3	upregulates	gene	0.85
CRISPR-Cas9	targets	process	0.85
RAB7A	interacts_with	protein	0.85
TIMM23 complex disruption	activates	mechanism	0.85
SIRT1	upregulates	protein	0.85
BAP31	interacts_with	protein	0.85
Hesperetin	upregulates	compound	0.85

Targeting Hypotheses (18)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PINK1/Parkin mitophagy failure across PD, AD, and ALS	0.796	multi	Cross-disease neurodegeneration mechanis
PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure Unifie	0.780	neurodegeneration	-
GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Si	0.747	neurodegeneration	-
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK	0.738	alzheimers	Cell type vulnerability in Alzheimers Di
OPTN/TBK1 mutations create selective vulnerability by blocki	0.670	neurodegeneration	What are the neuron-specific effects of

PINK1/Parkin-pathway mitophagy impairment in sporadic Parkin	0.630	neurodegeneration	Test
Dose-Response Framework: PINK1/Parkin Mitophagy as the Criti	0.614	neurodegeneration	What are the optimal oxygen pressure, du
Mitophagy collapse via PINK1-PRKN is the primary autophagy l	0.614	neurodegeneration	What specific autophagy pathways are def
PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflamma	0.571	neuroinflammation	Immune atlas neuroinflammation analysis
TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosoma	0.560	neurodegeneration	Does TRPML1 enhancement cause therapeuti
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor	0.529	neurodegeneration	Mitochondrial transfer between neurons a
Mitochondrial-Targeted PINK1/Parkin Pathway Activation for N	0.500	neurodegeneration	Test Hypothesis Fixtures
PINK1/PARK2-LC3 Mitophagy Enhancement	0.485	neuroinflammation	Immune atlas neuroinflammation analysis
USP13 Stabilization of PINK1/Parkin Mitophagy in Parkinson's	0.393	neurodegeneration	Test
Mitophagy Enhancement Blocks STING-Mediated Neuroinflammatio	0.380	neuroinflammation	Immune atlas neuroinflammation analysis
PINK1/PARK2 Mitophagy Enhancement for Microglial Polarizatio	0.380	neuroinflammation	Immune atlas neuroinflammation analysis
Combination Gene Therapy Targeting RGS6 and Parkin or PINK1	0.317	neurodegeneration	Does RGS6 upregulation or D2 autorecepto
Intercellular Mitophagy Communication Network	0.000	-	How do non-cell autonomous effects of au

Mentioning Analyses (10)

Scientific analyses that reference this entity

Cross-disease neurodegeneration mechanism synthesis

neurodegeneration | 2026-04-28 | 17 hypotheses Top: 0.828

What specific autophagy pathways are defective in radiation-induced pericyte sen

neurodegeneration | 2026-04-25 | 3 hypotheses Top: 0.652

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

neurodegeneration | 2026-04-11 | 0 hypotheses

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

neurodegeneration | 2026-04-11 | 0 hypotheses

Do transferred mitochondria from diseased astrocytes carry pathological damage t

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD	exploratory	Parkinson's disease	0.900	0.00	iPSC-derived dopaminergic neur	proposed	N/A
PINK1 mutation carriers frequently report experiencing pain.	genetic_association	Parkinson's disease	0.500	0.00	human	extracted	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730]	Zhang Y, Jiang H, Zhang F, Liao J	Neural regeneration research	2026	0
The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859]	Qi L, Yi J, Shen Y, Jiang H, Yao X et al	Biochem Pharmacol	2026	0
Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004]	Zhang H, Xiao J, Yi Y, Chen B, Lv W et a	Phytomedicine	2026	0
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005]	You T, Dai B, Ding X, He Z, Peng J et al	Phytomedicine	2026	0
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969]	Wang Y, Yuan Q	Clin Exp Pharmacol Physiol	2026	0
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899]	Yuanyuan Fang; Mengqiu Deng; Kesheng Hua	Cell communication and signali	2026	0
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653]	Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y	Journal of diabetes	2026	0
Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101]	Cheng YL, Su MS, Liao CC, Chang TW, Hsie	Journal of microbiology, immun	2026	0
Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436]	Shan C, Szili-Torok T, Yue G, Zhang L, M	Phytomedicine : international	2026	0
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550]	["Gao L", "Shen J", "Gao J", "Li T", "Ya	Antioxidants (Basel, Switzerla	2026	0
Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models v [PMID:41094045]	Li A, Huang S, Cao SQ, Lin J, Zhao L, Yu	EMBO molecular medicine	2025	0
Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627]	El-Mahrouk SR, El-Kadi AOS	Archives of toxicology	2025	0
Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796]	Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu	Journal of neuroinflammation	2025	0
Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261]	Yang R, Meng X, Zhao W, Xu SQ, Wang SY,	Bioorganic chemistry	2025	0
Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458]	Pradeepkiran JA, Kshirsagar S, Alvir RV,	Biochimica et biophysica acta.	2025	0
The effects of Honokiol on the liver of Alzheimer's disease mice by upregulating [PMID:40776632]	Wang H, Liu J, Tian YR, Zhu F, Li H	Journal of Alzheimer's disease	2025	0
Publisher Correction: Age and sex affect deep learning prediction of cardiometab [PMID:33414494]	Gerrits, Elen, Van Craenendonck, Trianta	Scientific Reports	2021	0
The human olfactory system in two proteinopathies: Alzheimer's and Parkinson's d [PMID:32493457]	Ubeda-Bañon I, Saiz-Sanchez D, Flores-Cu	Translational neurodegeneratio	2020	0
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation. [PMID:33168089]	Quinn PMJ, Moreira PI, Ambrósio AF, Alve	Acta neuropathologica communic	2020	0

Debates (17)

Multi-agent debates referencing this entity

Second debate: Microglial TREM2-SYK Pathway Enhancement

closed · Rounds: 4 · Score: 0.57 · 2026-04-28

Which AD, PD, ALS, and FTD mechanisms recur across disease boundaries and yield

closed · Rounds: 4 · Score: 0.72 · 2026-04-28

Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Primin

closed · Rounds: 4 · Score: 0.12 · 2026-04-27

Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE P

closed · Rounds: 4 · Score: 0.42 · 2026-04-27

Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability i

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

Debate: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes

closed · Rounds: 4 · Score: 0.47 · 2026-04-27

Should '40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Sele

closed · Rounds: 4 · Score: 0.52 · 2026-04-27

Should 'ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matt

closed · Rounds: 4 · Score: 0.72 · 2026-04-27

What specific autophagy pathways are defective in radiation-induced pericyte sen

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

The debate highlighted that mitochondrial transfer could be therapeutic, but rai

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

Related Research

Hypotheses and analyses mentioning PINK1 in their description or question text

PINK1

Understanding Entity Pages

Summary

Wiki Pages (16)

PINK1 Protein

PINK1-Parkin Mitophagy Pathway in Parkinson's Disease

PINK1-Parkin Mitophagy Complex

Mitophagy Gate Therapy: PINK1/Parkin + TFEB Priming

PINK1-Deficient Dopaminergic Neurons

PINK1 Activators for Parkinson's Disease

PINK1/PARKIN Mitophagy Activators for Parkinson's Disease

PINK1-Parkin Mitophagy Activators

PINK1 — PTEN Induced Kinase 1

PINK1

PINK1-Deficient Dopamine Neurons

PINK1/Parkin Pathway in Parkinson's Disease

PINK1/Parkin Activators

PINK1 (PTEN-Induced Kinase 1)

PINK1-Deficient Dopamine Neurons

PINK1 — PTEN Induced Kinase 1 (PARK6)

Pathway Diagram

Outgoing (1951)

Incoming (1607)

Targeting Hypotheses (18)

Mentioning Analyses (10)

Cross-disease neurodegeneration mechanism synthesis

What specific autophagy pathways are defective in radiation-induced pericyte sen

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

Do transferred mitochondria from diseased astrocytes carry pathological damage t

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Mitochondrial transfer between astrocytes and neurons

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Mechanistic role of APOE in neurodegeneration

Experiments (2)

Related Papers (20)

Debates (17)

Second debate: Microglial TREM2-SYK Pathway Enhancement

Which AD, PD, ALS, and FTD mechanisms recur across disease boundaries and yield

Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Primin

Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE P

Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability i

Debate: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes

Should '40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Sele

Should 'ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matt

What specific autophagy pathways are defective in radiation-induced pericyte sen

The debate highlighted that mitochondrial transfer could be therapeutic, but rai

Related Research

PINK1/Parkin-pathway mitophagy impairment in sporadic Parkinson's disease

Dose-Response Framework: PINK1/Parkin Mitophagy as the Critical Mediator Linking

Mitophagy collapse via PINK1-PRKN is the primary autophagy lesion after irradiat

PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflammation Control

TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosomal Biogenesis

PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor Mitochondria

Mitochondrial-Targeted PINK1/Parkin Pathway Activation for Neuroprotection

PINK1/PARK2-LC3 Mitophagy Enhancement

USP13 Stabilization of PINK1/Parkin Mitophagy in Parkinson's Disease

Mitophagy Enhancement Blocks STING-Mediated Neuroinflammation in ALS

PINK1/PARK2 Mitophagy Enhancement for Microglial Polarization

Combination Gene Therapy Targeting RGS6 and Parkin or PINK1 to Address Mitochond

Intercellular Mitophagy Communication Network