Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HERPUD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HERPUD1 is an ER protein critical for ER-associated degradation (ERAD), unfolded protein response, and protection against ER stress. Implicated in Alzheimer's, Parkinson's, and HSP.
| Gene Symbol | HERPUD1 |
| Full Name | Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Protein 1 |
| Chromosome | 16q13 |
| Function | is a critical ER membrane protein involved in ER-associated degradation (ERAD) and the unfolded protein response (UPR). |
| Molecular Weight | ~46 kDa |
| Amino Acids | 390 aa |
| UniProt ID | Q9Y5X5 |
| NCBI Gene ID | 9709 |
| Ensembl ID | ENSG00000128604 |
| OMIM | 607340 |
| GeneCards | HERPUD1 |
| Human Protein Atlas | HERPUD1 |
| Protein Class | ERAD component / UPR regulator |
| SEL1L | ERAD component |
| HRD1 | E3 ligase |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HERPUD1["HERPUD1"]
neurodegeneration["neurodegeneration"]
HERPUD1 -->|"implicated_in"| neurodegeneration
style HERPUD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||