Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HIF1A, NFKB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | associated_with | disease | 0.50 |
| IL1B, TNFA, NLRP3 | co_associated_with | gene | 0.40 |
| IGFBPL1 | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C1QA, C3, CX3CR1, CX3CL1 | co_associated_with | gene | 0.40 |
| GPR43, GPR109A | co_associated_with | gene | 0.40 |
| CLOCK, ARNTL | co_associated_with | gene | 0.40 |
| DNMT3A, HDAC1/2 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Perinatal Hypoxia-Primed Microglia Targeting | 0.385 | Alzheimer's disease | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The effect of ponicidin on CFA-induced chronic inflammatory pain and its mechani [PMID:40093024] | Wang P, Jiang H, Yao J, He G, Tao T et a | Front Med (Lausanne) | 2025 | 0 |
| Norsesquiterpenes from the stems and leaves of Pinellia pedatisecta Schott. [PMID:40543640] | Chen X, Cao YG, Chi FG, Liu YL, Ye KL et | Phytochemistry | 2025 | 0 |
| SCG5 and MITF may be novel markers of copper metabolism immunorelevance in Alzhe [PMID:38871989] | Zhuang X, Xia Y, Liu Y, Guo T, Xia Z et | Sci Rep | 2024 | 0 |
| Is there a future for andrographolide to be an anti-inflammatory drug? Decipheri [PMID:28377280] | Tan WSD, Liao W, Zhou S, Wong WSF | Biochem Pharmacol | 2017 | 0 |
| Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transge [PMID:28381639] | Singh SP, Chand HS, Langley RJ, Mishra N | J Immunol | 2017 | 0 |