concept

IGFBPL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGFBPL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

16Hypotheses

2Analyses

17Outgoing

16Incoming

1Experiments

3Debates

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💡 Concept Info

Name	IGFBPL1
Key Genes/Proteins	APOE, C1QA, C1QA, C3, CX3CR1, CX3CL1, CLOCK, ARNTL, DNMT3A, HDAC1/2, GPR43, GPR109A
Related Diseases	Alzheimer's disease, neurodegeneration
Related Pathways	neuroinflammation
Linked Hypotheses	13 hypotheses

🔮 Predicted Structure: IGFBPL1 — AlphaFold Q9Y6Q9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    IGFBPL1[IGFBPL1]
    IGFBPL1 -->|regulates| Microglial_Homeostasis[Microglial Homeostasis]
    IGFBPL1 -->|inhibits| Microglial_Activation[Microglial Activation]
    IGFBPL1 -->|regulates| Metabolic_Reprogramming[Metabolic Reprogramming]
    IGFBPL1 -->|stabilizes| Anti_Inflammatory_Transcriptio[Anti-Inflammatory Transcriptional Programs]
    IGFBPL1 -->|regulates| microglial_homeostasis[microglial_homeostasis]
    IGFBPL1 -->|associated_with_microglial_priming| Alzheimer_s_disease[Alzheimer's disease]
    IGFBPL1 -->|co_associated_with| TNF_IL6[TNF/IL6]
    IGFBPL1 -->|co_associated_with| Multiple[Multiple]
    IGFBPL1 -->|co_associated_with| TREM2[TREM2]
    IGFBPL1 -->|co_associated_with| IL1B__TNFA__NLRP3[IL1B, TNFA, NLRP3]
    h_d4ff5555[h-d4ff5555] -->|targets| IGFBPL1
    C1QA__C3__CX3CR1__CX3CL1[C1QA, C3, CX3CR1, CX3CL1] -->|co_associated_with| IGFBPL1
    CLOCK__ARNTL[CLOCK, ARNTL] -->|co_associated_with| IGFBPL1
    GPR43__GPR109A[GPR43, GPR109A] -->|co_associated_with| IGFBPL1
    HIF1A__NFKB1[HIF1A, NFKB1] -->|co_associated_with| IGFBPL1
    APOE[APOE] -->|co_associated_with| IGFBPL1
    C1QA[C1QA] -->|co_associated_with| IGFBPL1
    DNMT3A__HDAC1_2[DNMT3A, HDAC1/2] -->|co_associated_with| IGFBPL1
    h_6880f29b[h-6880f29b] -->|targets| IGFBPL1

Outgoing (17)

Target	Relation	Type	Str
h-1dd95a85f3	targeted_by	hypothesis	1.00
h-803b338102	targeted_by	hypothesis	1.00
h-21d655104e	targeted_by	hypothesis	1.00
h-cc077b4f0d	associated_with	hypothesis	1.00
h-811520b92f	targeted_by	hypothesis	1.00
h-37fc3b23a5	targeted_by	hypothesis	1.00
h-9d07f0457a	targeted_by	hypothesis	1.00
neuroinflammation	inhibits	mechanism	0.70
tau_pathology	prevents	mechanism	0.70
neuroinflammation	prevents	mechanism	0.70
microglial_homeostasis	regulates	cellular_process	0.50
Alzheimer's disease	associated_with_microglial_priming	disease	0.50
neurodegeneration	associated_with	disease	0.50
Multiple	co_associated_with	gene	0.40
TNF/IL6	co_associated_with	gene	0.40
TREM2	co_associated_with	gene	0.40
IL1B, TNFA, NLRP3	co_associated_with	gene	0.40

Incoming (16)

Source	Relation	Type	Str
h-9d07f0457a	targets	hypothesis	1.00
h-21d655104e	targets	hypothesis	1.00
h-811520b92f	targets	hypothesis	1.00
h-1dd95a85f3	targets	hypothesis	1.00
h-37fc3b23a5	targets	hypothesis	1.00
h-803b338102	targets	hypothesis	1.00
h-cc077b4f0d	targets	hypothesis	1.00
h-d4ff5555	targets	hypothesis	0.80
CLOCK, ARNTL	co_associated_with	gene	0.40
GPR43, GPR109A	co_associated_with	gene	0.40
HIF1A, NFKB1	co_associated_with	gene	0.40
APOE	co_associated_with	gene	0.40
C1QA	co_associated_with	gene	0.40
DNMT3A, HDAC1/2	co_associated_with	gene	0.40
h-6880f29b	targets	hypothesis	0.40
C1QA, C3, CX3CR1, CX3CL1	co_associated_with	gene	0.40

Targeting Hypotheses (16)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
AAV-PHP.eB-Mediated Microglial IGFBPL1 Expression	0.768	drug-delivery	Can IGFBPL1 therapeutics effectively cro
Focused Ultrasound with Microbubble Contrast Agents	0.684	drug-delivery	Can IGFBPL1 therapeutics effectively cro
IGFBPL1-Mediated Homeostatic Restoration	0.584	alzheimers	Neuroinflammation and microglial priming
IGFBPL1-Mediated Microglial Reprogramming	0.579	neurodegeneration	Neuroinflammation and microglial priming
Fusing IGFBPL1 to IGF-1 for Receptor-Mediated BBB Transcytos	0.552	drug-delivery	Can IGFBPL1 therapeutics effectively cro

Lipid Nanoparticle Encapsulation of IGFBPL1-mRNA	0.527	drug-delivery	Can IGFBPL1 therapeutics effectively cro
Intranasal IGFBPL1 Delivery via Olfactory Pathway	0.459	drug-delivery	Can IGFBPL1 therapeutics effectively cro
Monocyte Trojan Horse Cell Therapy	0.441	drug-delivery	Can IGFBPL1 therapeutics effectively cro
IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability	0.397	drug-delivery	Can IGFBPL1 therapeutics effectively cro
Ultrasound-Responsive Liposomal Nanocarriers with Thermosens	0.380	drug-delivery	Can IGFBPL1 therapeutics effectively cro
FUS-Enhanced AAV-PHP.eB Delivery for Microglial IGFBPL1 Expr	0.380	drug-delivery	Can IGFBPL1 therapeutics effectively cro
Lentiviral-Mediated Astrocytic IGFBPL1 Expression via GFAP P	0.380	drug-delivery	Can IGFBPL1 therapeutics effectively cro
AAV-PHP.eB-Mediated Astrocytic IGFBPL1 Expression	0.359	drug-delivery	Can IGFBPL1 therapeutics effectively cro
Magnetofection-Enhanced IGFBPL1 Delivery via Superparamagnet	0.341	drug-delivery	Can IGFBPL1 therapeutics effectively cro
FUS-Enhanced AAV-PHP.eB Delivery of IGFBPL1 to Microglia	0.338	drug-delivery	Can IGFBPL1 therapeutics effectively cro
IGFBPL1-Mediated Microglial Homeostasis Reset Therapy	0.000	-	Neuroinflammation and microglial priming

Mentioning Analyses (2)

Scientific analyses that reference this entity

Can IGFBPL1 therapeutics effectively cross the blood-brain barrier to reach CNS

drug delivery | 2026-04-06 | 13 hypotheses Top: 0.768

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 20 hypotheses Top: 0.651

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
bEV-mediated synaptic pruning via C1q-C3 pathway	exploratory	Alzheimer's disease	0.850	0.00	microglia and synapses (in viv	proposed	N/A

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Insulin-Like Growth Factor Signaling in Alzheimer's Disease: Pathophysiology and [PMID:39240280]	Miao J, Zhang Y, Su C, Zheng Q, Guo J	Molecular neurobiology	2025	1
IGF2BP1 exacerbates neuroinflammation and cerebral ischemia/reperfusion injury b [PMID:40294852]	Li Y, Jiang J, Zhuo Y, Li J, Li Y, Xia Y	Biochimica et biophysica acta.	2025	1
Functional assessments through novel proteomics approaches: Application to insul [PMID:30412730]	Ayyadevara S, Ganne A, Hendrix RD, Balas	Journal of neuroscience method	2019	1
Neuronal functions of FOXO/DAF-16. [PMID:28447066]	Kim SY, Webb AE	Nutrition and healthy aging	2017	1
Caloric restriction. [PMID:21840335]	Speakman JR, Mitchell SE	Molecular aspects of medicine	2011	1
Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pi [PMID:22039242]	Arroba AI, Alvarez-Lindo N, van Rooijen	Investigative ophthalmology &	2011	1
Semaglutide treatment reverses HFD induced hippocampal microglia activation and [PMID:41916100]	["Gong Haodong", "Liu Junlu", "Wang Yiha	Tissue & cell	2026	0
α-Synuclein oligomers potentiate neuroinflammatory NF-κB activity and induce Ca [PMID:38378800]	["Leandrou Emmanouela", "Chalatsa Ioanna	Translational neurodegeneratio	2024	0
IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinfla [PMID:37527036]	Pan L, Cho KS, Wei X, Xu F, Lennikov A,	Cell reports	2023	0

Debates (3)

Multi-agent debates referencing this entity

The debate highlighted IGFBPL1's potential as a microglial master regulator but

closed · Rounds: 4 · Score: 0.69 · 2026-04-22

Investigate mechanistic links between early microglial priming states, neuroinfl

closed · Rounds: 4 · Score: 0.86 · 2026-04-12

Investigate mechanistic links between early microglial priming states, neuroinfl

closed · Rounds: 5 · Score: 0.95 · 2026-04-12

Related Research

Hypotheses and analyses mentioning IGFBPL1 in their description or question text

Lipid Nanoparticle Encapsulation of IGFBPL1-mRNA

Score: 0.527 · drug-delivery · 2026-04-22

## Mechanistic Overview Lipid Nanoparticle Encapsulation of IGFBPL1-mRNA starts from the claim that modulating IGFBPL1 w

Intranasal IGFBPL1 Delivery via Olfactory Pathway

Score: 0.459 · drug-delivery · 2026-04-22

## Mechanistic Overview Intranasal IGFBPL1 Delivery via Olfactory Pathway starts from the claim that modulating IGFBPL1

Monocyte Trojan Horse Cell Therapy

Score: 0.441 · drug-delivery · 2026-04-22

## Mechanistic Overview Monocyte Trojan Horse Cell Therapy starts from the claim that modulating IGFBPL1 within the dise

IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability

Score: 0.397 · drug-delivery · 2026-04-22

## Mechanistic Overview IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability starts from the claim that modulating IG

Ultrasound-Responsive Liposomal Nanocarriers with Thermosensitive Release

Score: 0.380 · drug-delivery · 2026-04-27

This approach leverages thermosensitive liposomes (TSLs) loaded with IGFBPL1 that undergo controlled drug release when e

FUS-Enhanced AAV-PHP.eB Delivery for Microglial IGFBPL1 Expression

Score: 0.380 · drug-delivery · 2026-04-27

This hybrid approach combines focused ultrasound (FUS) microbubble-mediated blood-brain barrier (BBB) disruption with AA

Lentiviral-Mediated Astrocytic IGFBPL1 Expression via GFAP Promoter

Score: 0.380 · drug-delivery · 2026-04-27

**Molecular Mechanism and Rationale** The lentiviral-mediated delivery of IGFBPL1 to astrocytes utilizes the neurotropi

AAV-PHP.eB-Mediated Astrocytic IGFBPL1 Expression

Score: 0.359 · drug-delivery · 2026-04-26

**Molecular Mechanism and Rationale** The AAV-PHP.eB-mediated delivery of IGFBPL1 to astrocytes leverages the neurotrop

Magnetofection-Enhanced IGFBPL1 Delivery via Superparamagnetic Iron Oxide Nanopa

Score: 0.341 · drug-delivery · 2026-04-26

The molecular foundation of magnetofection-mediated IGFBPL1 delivery exploits superparamagnetic iron oxide nanoparticles

FUS-Enhanced AAV-PHP.eB Delivery of IGFBPL1 to Microglia

Score: 0.338 · drug-delivery · 2026-04-26

This hypothesis combines focused ultrasound (FUS) microbubble-mediated blood-brain barrier disruption with AAV-PHP.eB vi

IGFBPL1-Mediated Microglial Homeostasis Reset Therapy

Score: 0.000 · unknown disease · 2026-04-28

Targeted delivery of IGFBPL1 or its functional mimetics could serve as a master switch to restore microglial homeostasis