Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IGFBPL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| Microglial Homeostasis | regulates | mechanism | 0.80 |
| Microglial Activation | inhibits | mechanism | 0.70 |
| Metabolic Reprogramming | regulates | mechanism | 0.70 |
| Anti-Inflammatory Transcriptional Programs | stabilizes | mechanism | 0.70 |
| microglial_homeostasis | regulates | cellular_process | 0.50 |
| Alzheimer's disease | associated_with_microglial_priming | disease | 0.50 |
| neurodegeneration | associated_with | disease | 0.50 |
| TNF/IL6 | co_associated_with | gene | 0.40 |
| Multiple | co_associated_with | gene | 0.40 |
| TREM2 | co_associated_with | gene | 0.40 |
| IL1B, TNFA, NLRP3 | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-d4ff5555 | targets | hypothesis | 0.80 |
| C1QA, C3, CX3CR1, CX3CL1 | co_associated_with | gene | 0.40 |
| CLOCK, ARNTL | co_associated_with | gene | 0.40 |
| GPR43, GPR109A | co_associated_with | gene | 0.40 |
| HIF1A, NFKB1 | co_associated_with | gene | 0.40 |
| APOE | co_associated_with | gene | 0.40 |
| C1QA | co_associated_with | gene | 0.40 |
| DNMT3A, HDAC1/2 | co_associated_with | gene | 0.40 |
| h-6880f29b | targets | hypothesis | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| IGFBPL1-Mediated Homeostatic Restoration | 0.446 | Alzheimer's disease | Neuroinflammation and microglial priming |
| IGFBPL1-Mediated Microglial Reprogramming | 0.414 | neurodegeneration | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
drug delivery | 2026-04-06 | 0 hypotheses
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Insulin-Like Growth Factor Signaling in Alzheimer's Disease: Pathophysiology and [PMID:39240280] | Miao J, Zhang Y, Su C, Zheng Q, Guo J | Molecular neurobiology | 2025 | 1 |
| IGF2BP1 exacerbates neuroinflammation and cerebral ischemia/reperfusion injury b [PMID:40294852] | Li Y, Jiang J, Zhuo Y, Li J, Li Y, Xia Y | Biochimica et biophysica acta. | 2025 | 1 |
| Functional assessments through novel proteomics approaches: Application to insul [PMID:30412730] | Ayyadevara S, Ganne A, Hendrix RD, Balas | Journal of neuroscience method | 2019 | 1 |
| Neuronal functions of FOXO/DAF-16. [PMID:28447066] | Kim SY, Webb AE | Nutrition and healthy aging | 2017 | 1 |
| Caloric restriction. [PMID:21840335] | Speakman JR, Mitchell SE | Molecular aspects of medicine | 2011 | 1 |
| Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pi [PMID:22039242] | Arroba AI, Alvarez-Lindo N, van Rooijen | Investigative ophthalmology & | 2011 | 1 |
| Semaglutide treatment reverses HFD induced hippocampal microglia activation and [PMID:41916100] | ["Gong Haodong", "Liu Junlu", "Wang Yiha | Tissue & cell | 2026 | 0 |
| α-Synuclein oligomers potentiate neuroinflammatory NF-κB activity and induce Ca [PMID:38378800] | ["Leandrou Emmanouela", "Chalatsa Ioanna | Translational neurodegeneratio | 2024 | 0 |
| IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinfla [PMID:37527036] | Pan L, Cho KS, Wei X, Xu F, Lennikov A, | Cell reports | 2023 | 0 |