Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HNRNPR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Heterogeneous nuclear ribonucleoprotein R - RNA processing gene implicated in ALS and neurodegeneration
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| Gene Symbol | HNRNPR |
| Aliases | Heterogeneous nuclear ribonucleoprotein R |
| Chromosome | 1p36.22 |
| Protein Type | Gene |
| Function | is a gene located on chromosome 1p36. |
| Molecular Weight | 70 kDa |
| Amino Acids | 644 aa |
| Exons | 15 |
| GeneCards | HNRNPR |
| Human Protein Atlas | HNRNPR |
| N-terminal region | Contains a prion-like domain with low complexity sequences that mediate protein-protein interactions |
| RNA Recognition Motifs (RRMs) | Four RRMs (RRM1-4) in the central and C-terminal regions that provide RNA binding specificity |
| C-terminal glycine-rich region | Involved in protein-protein interactions and nuclear localization |
| Synaptic protein isoforms | Regulation of splice variants for receptors, ion channels, and scaffolding proteins |
| Cytoskeletal proteins | Alternative splicing of tau and microtubule-associated proteins |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HNRNPR["HNRNPR"]
neurodegeneration["neurodegeneration"]
HNRNPR -->|"implicated_in"| neurodegeneration
style HNRNPR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HNRNPR in their description or question text
No additional research found