gene

HRK

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HRK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for HRK Gene

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🧬 Gene Info

Gene Symbol	HRK
Full Name	Harakiri, Bcl-2 interacting protein
Chromosome	12q24.12
Function	encodes a pro-apoptotic member of the Bcl-2 family of proteins.
Primary Expression	various tissues but is particularly important in the nervous system, where it regulates developmental neuronal apoptosis and contributes to pathologic
Molecular Weight	9.5 kDa
Amino Acids	20 aa
UniProt ID	[Q9GZK8](https://www.uniprot.org/uniprot/Q9GZK8)
GeneCards	HRK
Human Protein Atlas	HRK
BH3-only protein	Binds to anti-apoptotic Bcl-2 family members
Bcl-2 neutralization	Prevents Bcl-2 from inhibiting Bax/Bak
Direct activation	May directly activate pro-apoptotic Bax/Bak
Mitochondrial pathway	Promotes cytochrome c release
Developmental apoptosis	Regulates naturally occurring neuronal death during development
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Cancer
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HRK Gene

gene · 842 words

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HRK Protein

protein · 1019 words

→

Pathway Diagram

graph TD
    HRK["HRK"]
    neurodegeneration["neurodegeneration"]
    HRK -->|"implicated_in"| neurodegeneration
    style HRK fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning HRK in their description or question text

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