gene

HTR1D

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR1D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

5Outgoing

0Incoming

0Experiments

Summary

Page for htr1d Gene

View on Wiki →

🧬 Gene Info

Gene Symbol	HTR1D
Full Name	5-Hydroxytryptamine Receptor 1D
Chromosome	1p36.12
Protein Family	5-HT1 receptor family (GPCR)
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	CNS, trigeminal nerve, cranial blood vessels
Molecular Weight	41 kDa
Amino Acids	377 aa
UniProt ID	P28221
NCBI Gene ID	3352
Ensembl ID	ENSG00000168594
GeneCards	HTR1D
Human Protein Atlas	HTR1D
Protein Class	G protein-coupled receptor
Associated Diseases	neurodegeneration
Interactions	Rb, DEPRESSION, C-FOS
KG Connections	5 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HTR1D — AlphaFold P28221 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HTR1D(["HTR1D"])
    DEPRESSION(["DEPRESSION"])
    NEURON(["NEURON"])
    C_FOS(["C-FOS"])
    Rb(["Rb"])
    Thalamus["Thalamus"]
    neurodegeneration["neurodegeneration"]

    HTR1D -.->|"inhibits"| DEPRESSION
    HTR1D -->|"associated with"| NEURON
    HTR1D -.->|"inhibits"| C_FOS
    HTR1D -.->|"inhibits"| Rb
    HTR1D -->|"expressed in"| Thalamus
    HTR1D -->|"implicated in"| neurodegeneration

    style HTR1D fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
Rb	inhibits	protein	0.60
DEPRESSION	inhibits	gene	0.60
NEURON	associated_with	gene	0.60
C-FOS	inhibits	gene	0.60
Thalamus	expressed_in	brain_region	0.55

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HTR1D

Understanding Entity Pages

Summary

Wiki Pages (6)

htr1d Gene

Serotonin 5-HT1D Receptor Neurons

htr1d Protein

htr1b Protein

Proteins