Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DEPRESSION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DEPRESSION is a disease characterized by neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 1032 entities in the SciDEX knowledge graph.
| Prevalence | ~280 million people worldwide |
| Morphology | immature neuron (source: Cell Ontology) |
| Associated Genes | HTTLPR, APOPTOSIS, CX3CR1, ASTROCYTE, AUTOPHAGY, AMYLOID, APP, ALZHEIMER'S DISEASE |
| Therapeutic Agents | ANTIDEPRESSANTS, (R)-KETAMINE, LITHIUM |
| KG Connections | 2841 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
flowchart TD
DEPRESSION(["DEPRESSION"])
Alzheimer["Alzheimer"]
Depression["Depression"]
Anxiety["Anxiety"]
Inflammation["Inflammation"]
Parkinson["Parkinson"]
Als["Als"]
DEPRESSION -->|"associated with"| Alzheimer
DEPRESSION -->|"associated with"| Depression
DEPRESSION -->|"associated with"| Anxiety
DEPRESSION -.->|"inhibits"| Depression
DEPRESSION -->|"regulates"| Depression
DEPRESSION -->|"contributes to"| Depression
DEPRESSION -->|"activates"| Inflammation
DEPRESSION -->|"associated with"| Parkinson
DEPRESSION -->|"activates"| Depression
DEPRESSION -->|"associated with"| Inflammation
DEPRESSION -->|"associated with"| Als
DEPRESSION -->|"interacts with"| Depression
DEPRESSION -->|"therapeutic target"| Als
DEPRESSION -->|"activates"| Als
DEPRESSION -->|"therapeutic target"| Depression
style DEPRESSION fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 1.00 |
| Depression | associated_with | disease | 1.00 |
| Anxiety | associated_with | disease | 1.00 |
| Depression | inhibits | disease | 1.00 |
| Depression | regulates | disease | 1.00 |
| Depression | contributes_to | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Depression | activates | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Depression | interacts_with | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Depression | therapeutic_target | disease | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Depression | treats | disease | 1.00 |
| Neurogenesis | activates | pathway | 1.00 |
| MICROGLIA | activates | cell_type | 1.00 |
| Aging | associated_with | disease | 0.95 |
| Dementia | associated_with | disease | 0.95 |
| Tumor | activates | disease | 0.95 |
| Aging | activates | disease | 0.95 |
| Neurodegeneration | associated_with | disease | 0.95 |
| Cancer | associated_with | disease | 0.95 |
| Neurodegeneration | therapeutic_target | disease | 0.95 |
| Inflammation | therapeutic_target | disease | 0.95 |
| Als | inhibits | disease | 0.95 |
| Als | regulates | disease | 0.95 |
| Parkinson | therapeutic_target | disease | 0.95 |
| Depression | expressed_in | disease | 0.95 |
| Depression | causes | disease | 0.95 |
| Stroke | associated_with | disease | 0.95 |
| Als | implicated_in | disease | 0.95 |
| HIPPOCAMPUS | activates | brain_region | 0.95 |
| Synaptic Plasticity | associated_with | pathway | 0.90 |
| Synaptic Plasticity | activates | pathway | 0.90 |
| Mapk | activates | pathway | 0.90 |
| Oxidative Stress | activates | pathway | 0.90 |
| Schizophrenia | associated_with | disease | 0.85 |
| Alzheimer | activates | disease | 0.85 |
| Inflammation | regulates | disease | 0.85 |
| Anxiety | causes | disease | 0.85 |
| Depression | biomarker_for | disease | 0.85 |
| Neurodegeneration | activates | disease | 0.85 |
| Aging | therapeutic_target | disease | 0.85 |
| Parkinson | inhibits | disease | 0.85 |
| Cardiovascular | activates | disease | 0.85 |
| Cancer | causes | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AMYLOID | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| ANXIETY | associated_with | gene | 1.00 |
| MICROGLIA | associated_with | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| BDNF | associated_with | gene | 1.00 |
| BDNF | therapeutic_target | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| ASTROCYTES | associated_with | cell_type | 1.00 |
| IL-6 | associated_with | gene | 1.00 |
| ASTROCYTE | activates | gene | 1.00 |
| EXERCISE | therapeutic_target | gene | 1.00 |
| ANXIETY | interacts_with | disease | 0.95 |
| JUN | associated_with | gene | 0.90 |
| TNF | associated_with | gene | 0.90 |
| NEURODEGENERATION | associated_with | gene | 0.90 |
| NF-KB | associated_with | protein | 0.90 |
| BDNF | protects_against | entity | 0.90 |
| SEROTONIN | associated_with | entity | 0.90 |
| Bifidobacterium breve | reduces | organism | 0.90 |
| STRESS | causes | process | 0.90 |
| GENES | associated_with | gene | 0.90 |
| NEURODEGENERATION | therapeutic_target | gene | 0.90 |
| TRKB | activates | gene | 0.90 |
| STROKE | associated_with | gene | 0.90 |
| OXIDATIVE STRESS | activates | gene | 0.90 |
| CREB | activates | gene | 0.90 |
| BDNF | treats | protein | 0.89 |
| RELN | implicated_in | entity | 0.85 |
| APOPTOSIS | associated_with | gene | 0.82 |
| REELIN | implicated_in | protein | 0.80 |
| BDNF | alleviates | gene | 0.80 |
| BDNF | downregulates | gene | 0.80 |
| indole-3-lactic acid | protects_against | compound | 0.80 |
| ADENOSINE | causes | compound | 0.80 |
| NLRP1 | implicated_in | gene | 0.80 |
| AUTOPHAGY | contributes_to | process | 0.80 |
| gut microbiota | linked_to | cell_type | 0.80 |
| indole-3-lactic acid | biomarker_for | compound | 0.80 |
| Parkinson's disease | comorbid_with | disease | 0.80 |
| acute sleep deprivation | exacerbates | process | 0.80 |
| MICROBIOTA | implicated_in | cell_type | 0.80 |
| OBESITY | increases_risk | disease | 0.80 |
| OGT | biomarker_for | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||