protein

HTR6PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR6PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Htr6 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	HTR6PROTEIN
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the brain, particularly in areas important for cognition and emotion (olfactory tubercle, nucleus accumbens, striatum, hippocampus)
Subcellular Localization	Unlike most 5-HT receptors, HTR6 exclusively couples to Gs proteins, making it u
Molecular Weight	50 kDa
GeneCards	HTR6PROTEIN
Human Protein Atlas	HTR6PROTEIN
Differential splicing	Generates isoforms with distinct pharmacological profiles
Cysteine residues	In extracellular loops for disulfide bond formation
Palmitoylation sites	For membrane localization
Cognitive enhancement	Hippocampal and cortical signaling improves learning and memory
Mood regulation	Modulates serotonergic signaling in limbic regions
Food intake	Hypothalamic HTR6 regulates appetite
Neuroprotection	May have trophic effects on neurons
Associated Diseases	Bipolar
KG Connections	7 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

htr6 Protein

protein · 561 words

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Pathway Diagram

graph TD
    HTR6PROTEIN["HTR6PROTEIN"]
    neurodegeneration["neurodegeneration"]
    HTR6PROTEIN -->|"implicated_in"| neurodegeneration
    style HTR6PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HTR6PROTEIN in their description or question text

No additional research found