Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL1A, TNF, C1Q: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| SNCA | co_associated_with | gene | 0.40 |
| WNT3A, CTNNB1, TCF7L2 | co_associated_with | gene | 0.40 |
| PDK1, PFKFB3, LDHA | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE4 | co_associated_with | gene | 0.40 |
| CST, GAL3ST1 | co_associated_with | gene | 0.40 |
| DAP12, SYK, PLCG2 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte-Microglia Communication Rebalancing via Cytokine M | 0.490 | neurodegeneration | Which cell types show the most significa |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.529
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| IL1A enhances TNF-induced retinal ganglion cell death. [PMID:41728092] | Andersh KM, MacLean M, Howell GR, Libby | Front Aging Neurosci | 2026 | 0 |
| IL1A enhances TNF-induced retinal ganglion cell death. [PMID:38854045] | Andersh KM, MacLean M, Howell GR, Libby | bioRxiv | 2024 | 0 |
| Dietary Polyphenols Decrease Chemokine Release by Human Primary Astrocytes Respo [PMID:37765263] | Grabarczyk M, Ksiazek-Winiarek D, Glabin | Pharmaceutics | 2023 | 0 |
| Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimu [PMID:35892669] | Szpakowski P, Ksiazek-Winiarek D, Turnia | Biomedicines | 2022 | 0 |