protein

IP3RPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IP3RPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	IP3RPROTEIN
Protein Type	Channel
Function	is a large calcium release channel located on the endoplasmic reticulum (ER) membrane.
Molecular Weight	314 kDa
GeneCards	IP3RPROTEIN
Human Protein Atlas	IP3RPROTEIN
N-terminal IP₃-binding domain	High-affinity IP₃ binding (suppressor domain)
Large regulatory domain	Contains regulatory sites for Ca²⁺, ATP, and modulators
Central modulatory domain	Includes IRAG (IP₃R-associated protein) binding
Six transmembrane domains (TM1-6)	Form the ion channel pore
C-terminal gatekeeper domain	Channel gating regulation
IP₃R1	Brain, cerebellum (highest expression)
IP₃R2	Glial cells, liver, cardiac muscle
IP₃R3	Widespread, secretory cells
Associated Diseases	neurodegeneration
Interactions	BCL2, CKB
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IP₃ Receptor Protein

protein · 537 words

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Pathway Diagram

graph TD
    IP3RPROTEIN["IP3RPROTEIN"]
    neurodegeneration["neurodegeneration"]
    IP3RPROTEIN -->|"implicated_in"| neurodegeneration
    style IP3RPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning IP3RPROTEIN in their description or question text

No additional research found