gene

BCL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2787Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

B-cell lymphoma 2 - anti-apoptotic protein critical for neuronal survival in neurodegeneration

View on Wiki →

🧬 Gene Info

Gene Symbol	BCL2
Aliases	B-cell lymphoma 2
Protein Family	BCL-2 family (anti-apoptotic subfamily)
Function	Direct BAX/BAK inhibition
Molecular Weight	26 kDa
Pathways	Akt, Apoptosis, Autophagy, BMP signaling, Bh4 Domain
UniProt ID	P10415
GeneCards	BCL2
Human Protein Atlas	BCL2
BH3 domain	Required for interaction with pro-apoptotic family members
Transmembrane domain	Anchors BCL2 to the outer mitochondrial membrane, ER, and nuclear envelope
BH1 domain	Forms part of the hydrophobic pocket that binds BH3 domains
BH2 domain	Contributes to the binding interface for pro-apoptotic proteins
N-terminal flexible region	Contains regulatory sequences
Phosphorylation	BCL2 is phosphorylated on multiple serine/threonine residues
Associated Diseases	AD, ALI, ALS, AUTOPHAGY, Aging
Known Drugs/Compounds	RAPAMYCIN, BERBERINE, R-PE, cadmium, magnolol, Tirzepatide
Interactions	LMNA, STING1, TAX1BP1, ATM, SNCAIP, RB1CC1
KG Connections	2784 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BCL2 — AlphaFold P10415 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BCL2["BCL2"] -->|"expressed in"| MITOCHONDRIA["MITOCHONDRIA"]
    BCL2["BCL2"] -.->|"inhibits"| BECN1["BECN1"]
    BCL2["BCL2"] -->|"interacts"| Dementia["Dementia"]
    BCL2["BCL2"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    BCL2["BCL2"] -->|"interacts"| Als["Als"]
    BCL2["BCL2"] -->|"interacts"| Alzheimer["Alzheimer"]
    STAT3["STAT3"] -->|"regulates"| BCL2["BCL2"]
    BMAL1["BMAL1"] -->|"regulates"| BCL2["BCL2"]
    CAT["CAT"] -->|"interacts"| BCL2["BCL2"]
    OPTN["OPTN"] -->|"interacts"| BCL2["BCL2"]
    style BCL2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1857)

Target	Relation	Type	Str
CASP3	associated_with	gene	1.00
Cancer	inhibits	disease	1.00
Apoptosis	inhibits	pathway	1.00
Leukemia	inhibits	disease	1.00
Tumor	activates	disease	1.00
Cancer	activates	disease	1.00
Tumor	inhibits	disease	1.00
Autophagy	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
Tumor	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Leukemia	therapeutic_target	disease	1.00
Apoptosis	therapeutic_target	pathway	1.00
Als	activates	disease	1.00
Als	regulates	disease	1.00
Cancer	regulates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
CANCER	inhibits	gene	1.00
Lymphoma	activates	disease	1.00
AKT	therapeutic_target	gene	1.00
Oxidative Stress	activates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
Intrinsic Apoptosis	regulates	pathway	0.98
AMBRA1	binds	protein	0.95
Cytochrome C Release	regulates	process	0.95
chronic lymphocytic leukaemia	therapeutic_target	disease	0.95
chronic lymphocytic leukemia	therapeutic_target	disease	0.95
cancer	therapeutic_target	disease	0.95
cell survival	regulates	process	0.95
cytochrome c release	regulates	process	0.95
Cytochrome C	regulates	protein	0.95
Als	inhibits	disease	0.95
Lymphoma	associated_with	disease	0.95
Cancer	associated_with	disease	0.95
acute myeloid leukemia	therapeutic_target	disease	0.92
acute myeloid leukemia	biomarker_for	disease	0.92
Mitochondrial Outer Membrane Permeabilization	causes	process	0.90
Macroautophagy	inhibits	process	0.90
BECLIN1	binds	protein	0.90
IP3R	binds	protein	0.90
retinal cell death	protects_against	process	0.90
cancer cell death	inhibits	process	0.90
mantle cell lymphoma	therapeutic_target	disease	0.90
diffuse large B-cell lymphoma	associated_with	disease	0.90
intrinsic apoptosis pathway	upstream_of	pathway	0.90
proapoptotic proteins	interacts_with	protein	0.90
Mitochondrial Apoptosis	regulates	process	0.90
apoptosis	inhibits	phenotype	0.90
apoptosis	regulates	phenotype	0.90

Incoming (930)

Source	Relation	Type	Str
APOPTOSIS	associated_with	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
TP53	interacts_with	protein	1.00
T3 (triiodothyronine)	increases	drug	0.95
venetoclax	inhibits	drug	0.95
ABT263	inhibits	drug	0.95
Cyclosporine A	downregulates	drug	0.92
HB68	downregulates	compound	0.92
HB147	downregulates	compound	0.92
gallic acid	associated_with	drug	0.90
R-phycoerythrin	associated_with	drug	0.90
CTSG	inhibits	protein	0.90
Abt263	inhibits	drug	0.90
Venetoclax	inhibits	drug	0.90
BH3-Mimetics	targets	compound	0.90
venetoclax	binds_to	drug	0.90
sonrotoclax	binds_to	drug	0.90
Rotenone	downregulates	compound	0.90
Bh3-Mimetics	targets	compound	0.90
cardamom nanoemulsion	downregulates	compound	0.90
STAT3	activates	gene	0.90
PI3K	therapeutic_target	gene	0.90
PI3K	activates	gene	0.90
PI3K	regulates	protein	0.90
OXIDATIVE STRESS	activates	gene	0.90
JAK2/STAT3 Signaling Pathway	upregulates	pathway	0.88
BCL-xL	coexpressed_with	protein	0.87
MCL1	coexpressed_with	protein	0.87
melamine	downregulates	compound	0.87
BMAL1	upregulates	gene	0.85
LYPLAL1-DT	activates	gene	0.85
BPF	binds_to	drug	0.85
miR-195	downregulates	gene	0.85
TP53	binds_to	protein	0.85
SQDS	upregulates	drug	0.85
sonrotoclax	inhibits	drug	0.85
lisaftoclax	inhibits	drug	0.85
Bisphenol F	binds	compound	0.85
Nomilin	binds	compound	0.85
Protacs	targets	compound	0.85
Adcs	targets	compound	0.85
HB147	targets	compound	0.85
AKR1B10	regulates	gene	0.85
Oxidative Stress	downregulates	process	0.85
BAX	associated_with	gene	0.82
LRWE	regulates	drug	0.80
R-PE	inhibits	drug	0.80
MTOR	activates	protein	0.80
BAX	regulates	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BCL2

Understanding Entity Pages

Summary

Wiki Pages (21)

BCL2 Gene

NTF4 Protein

Mitochondrial Quality Control

Mitophagy Pathway in Neurodegeneration

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

mitophagy-defect

Mitophagy Pathway in Neurodegeneration

CBS/PSP Genetic Architecture

Mitochondria in Neurodegeneration

Cytochrome c Protein

BAG5 Gene

GLI1 — GLI Family Zinc Finger 1

lmx1b

Apoptosis Pathway in Neurodegeneration

Combination Therapy Synergies for CBS/PSP

Hedgehog Signaling in Neurodegeneration

Estrogen Signaling in Neurodegeneration