Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNAB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KCNAB3 encodes the β3 auxiliary subunit of voltage-gated potassium channels, modulating neuronal excitability, synaptic transmission, and potentially contributing to neurodegenerative disease pathways.
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| Gene Symbol | KCNAB3 |
| Full Name | Potassium Voltage-Gated Channel Subfamily A Member Beta 3 |
| Chromosome | 17p13.1 |
| Function | modulating neuronal excitability |
| Primary Expression | neuronal tissues where it plays critical roles in regulating neuronal excitability, action potential repolarization, and synaptic transmission[@mcgowa |
| Subcellular Localization | Within neurons, KCNAB3 localizes to specific compartments[@redman2011]: |
| Molecular Weight | 44.5 kDa |
| Amino Acids | 403 aa |
| UniProt ID | O43512 |
| NCBI Gene ID | 9170 |
| Ensembl ID | ENSG00000170075 |
| OMIM | 604375 |
| GeneCards | KCNAB3 |
| Human Protein Atlas | KCNAB3 |
| KCNAB1 (Kvβ1) | Widely expressed, induces fast inactivation |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNAB3["KCNAB3"]
neurodegeneration["neurodegeneration"]
KCNAB3 -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning KCNAB3 in their description or question text
No additional research found