gene

KCNE4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNE4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

KCNE4 is a regulatory subunit of voltage-gated potassium channels that modulates channel activity in the brain and heart, with implications for neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	KCNE4
Chromosome	2q36.1
Function	is a critical regulatory subunit that modulates the function of various voltage-gated potassium (Kv) channels.
Primary Expression	both cardiac and neuronal tissues where it plays crucial roles in regulating excitability and cellular function[@abbott2018]
Molecular Weight	21 kDa
Amino Acids	180 aa
Exons	3
UniProt ID	Q9P110
NCBI Gene ID	23704
OMIM	607334
GeneCards	KCNE4
Human Protein Atlas	KCNE4
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNE4 — AlphaFold Q9P110 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNE4 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4)

gene · 1570 words

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KCNE4 Protein

protein · 733 words

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Pathway Diagram

graph TD
    KCNE4["KCNE4"]
    neurodegeneration["neurodegeneration"]
    KCNE4 -->|"implicated_in"| neurodegeneration
    style KCNE4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNE4 in their description or question text

No additional research found