gene

KCNE5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNE5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

KCNE5 encodes a regulatory subunit of voltage-gated potassium channels, important for neuronal excitability and linked to cardiac arrhythmia and neurodegeneration

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🧬 Gene Info

Gene Symbol	KCNE5
Full Name	Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 5
Chromosome	Xq23
Protein Type	Channel
Function	is a gene that encodes a regulatory subunit of voltage-gated potassium (Kv) channels.
Primary Expression	various excitatory and inhibitory neurons - Brain regions: Detected in cortex, hippocampus, cerebellum - Subcellular: Localized to dendritic a
Subcellular Localization	dendritic and somatic membranes
Molecular Weight	14 kDa
Amino Acids	144 aa
UniProt ID	[Q9NZZ6](https://www.uniprot.org/uniprot/Q9NZZ6)
Ensembl ID	ENSG00000124145
GeneCards	KCNE5
Human Protein Atlas	KCNE5
Single transmembrane domain	Spans the lipid bilayer
N-terminal extracellular domain	Short, with potential glycosylation sites
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNE5 — Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 5

gene · 938 words

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KCNE5 Protein

protein · 695 words

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Pathway Diagram

graph TD
    KCNE5["KCNE5"]
    neurodegeneration["neurodegeneration"]
    KCNE5 -->|"implicated_in"| neurodegeneration
    style KCNE5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNE5 in their description or question text

No additional research found