protein

KCNK10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNK10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

12Outgoing

5Incoming

Summary

Page for KCNK10 Protein

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🔬 Protein Info

Gene Symbol	KCNK10
Full Name	Potassium Two Pore Domain Channel Subfamily K Member 10
Chromosome	3p24.3
Function	The KCNK10 gene encodes the potassium two pore domain channel subfamily K member 10, also known as TASK-3 (TWIK-related acid-sensitive potassium channel 3).
Primary Expression	substantia nigra dopaminergic neurons - TASK-3 currents protect against MPTP-induced parkinsonism in mice - May modulate neuronal vulnerability to oxi
Molecular Weight	56 kDa
Pathways	Cellular Excitability, Potassium Ion Transport, Temperature Gating
UniProt ID	[Q9NPC6](https://www.uniprot.org/uniprot/Q9NPC6)
Ensembl ID	ENSG00000100417
GeneCards	KCNK10
Human Protein Atlas	KCNK10
Associated Diseases	neurodegeneration
Interactions	KCNK2, NEURODEGENERATION, TREK-1
KG Connections	17 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KCNK10["<b>KCNK10</b>"]
    Neurodegeneration{"Neurodegeneration"}
    KCNK10 -->|"activates"| Neurodegeneration
    KCNK10 -->|"regulates"| Neurodegeneration
    KCNK2["KCNK2"]
    KCNK10 -->|"activates"| KCNK2
    KCNK10 -->|"regulates"| KCNK2
    AND["AND"]
    KCNK10 -->|"associated with"| AND
    NEURODEGENERATION["NEURODEGENERATION"]
    KCNK10 -->|"activates"| NEURODEGENERATION
    neurodegeneration["neurodegeneration"]
    KCNK10 -->|"implicated in"| neurodegeneration
    KCNK2 -->|"activates"| KCNK10
    NEURODEGENERATION -->|"activates"| KCNK10
    style KCNK10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Potassium Ion Transport	involved_in	process	0.95
Cellular Excitability	regulates	process	0.95
potassium leak	mediates	process	0.95
Temperature Gating	involved_in	mechanism	0.90
cellular excitability	modulates	phenotype	0.85
Neurodegeneration	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
KCNK2	activates	gene	0.60
KCNK2	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
TREK-1	activates	gene	0.60
AND	associated_with	gene	0.60

Incoming (5)

Source	Relation	Type	Str
Heat	activates	phenotype	0.95
KCNK2	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
KCNK2	regulates	gene	0.50
TREK-1	regulates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KCNK10

Understanding Entity Pages

Summary

Wiki Pages (8)

KCNK10 Gene

KCNK18 — Potassium Two Pore Domain Channel Subfamily K Member 18 (TRESK)

KCNK17 Protein

KCNK16 Protein

TREK-1 Protein

KCNK10 Protein