TREK-1

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREK-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TREK-1 is a protein involved in neurodegeneration research. Key relationships include: regulates, modulates, expressed in. Associated with Corticosteroid-Induced Ocular Hypertension, Influenza A-Induced Lung Injury, OHT. Connected to 26 entities in the SciDEX knowledge graph.

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graph TD
    TREK_1["<b>TREK-1</b>"]
    Conventional_Outflow(["Conventional Outflow"])
    TREK_1 -->|"regulates"| Conventional_Outflow
    Intraocular_Pressure["Intraocular Pressure"]
    TREK_1 -->|"regulates"| Intraocular_Pressure
    Adipocyte_Differentiation(["Adipocyte Differentiation"])
    TREK_1 -->|"regulates"| Adipocyte_Differentiation
    Lipid_Accumulation["Lipid Accumulation"]
    TREK_1 -->|"regulates"| Lipid_Accumulation
    Influenza_A_Induced_Lung_Injury{"Influenza A-Induced Lung Injury"}
    TREK_1 -->|"protects against"| Influenza_A_Induced_Lung_Injury
    Adipocytes["Adipocytes"]
    TREK_1 -->|"expressed in"| Adipocytes
    Trabecular_Meshwork["Trabecular Meshwork"]
    TREK_1 -->|"expressed in"| Trabecular_Meshwork
    Ca2__Influx(["Ca2+ Influx"])
    TREK_1 -->|"inhibits"| Ca2__Influx
    Cell_Membrane_Potential_Hyperpolarizatio(["Cell Membrane Potential Hyperpolarization"])
    TREK_1 -->|"mediates"| Cell_Membrane_Potential_Hyperpolarizatio
    Corticosteroid_Induced_Ocular_Hypertensi{"Corticosteroid-Induced Ocular Hypertension"}
    TREK_1 -->|"contributes to"| Corticosteroid_Induced_Ocular_Hypertensi
    Cell_Membrane_Electrical_Potential["Cell Membrane Electrical Potential"]
    TREK_1 -->|"modulates"| Cell_Membrane_Electrical_Potential
    Inflammatory_Response(["Inflammatory Response"])
    TREK_1 -->|"modulates"| Inflammatory_Response
    Spadin["Spadin"]
    Spadin -->|"inhibits"| TREK_1
    BL1249["BL1249"]
    BL1249 -->|"activates"| TREK_1
    ML335["ML335"]
    ML335 -->|"activates"| TREK_1
    Mechanosensation(["Mechanosensation"])
    Mechanosensation -->|"involved in"| TREK_1
    Glucocorticoids["Glucocorticoids"]
    Glucocorticoids -->|"modulates"| TREK_1
    KCNK2["KCNK2"]
    KCNK2 -->|"encodes"| TREK_1
    RPL31["RPL31"]
    RPL31 -->|"interacts with"| TREK_1
    MBD1["MBD1"]
    MBD1 -->|"binds"| TREK_1
    ML_402["ML-402"]
    ML_402 -->|"activates"| TREK_1
    PrPC["PrPC"]
    PrPC -->|"interacts with"| TREK_1
    style TREK_1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0