gene

KCNK18

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNK18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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Summary

Comprehensive coverage of KCNK18 (TRESK), a two-pore domain potassium channel in sensory neurons, implicated in migraine, epilepsy, neuropathic pain, and neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	KCNK18
Full Name	Potassium Two Pore Domain Channel Subfamily K Member 18 (TRESK)
Aliases	TRESK
Chromosome	10q26.3
Protein Type	Channel
Function	is a background potassium channel that contributes to the resting membrane potential and regulates neuronal excitability.
Molecular Weight	38 kDa
Amino Acids	380 aa
Exons	4
GeneCards	KCNK18
Human Protein Atlas	KCNK18
Associated Diseases	Epilepsy
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNK18 — Potassium Two Pore Domain Channel Subfamily K Member 18 (TRESK)

gene · 2933 words

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KCNK18 Protein - Potassium Two Pore Domain Channel Subfamily K Member 18

protein · 1754 words

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Pathway Diagram

graph TD
    KCNK18["KCNK18"]
    neurodegeneration["neurodegeneration"]
    KCNK18 -->|"implicated_in"| neurodegeneration
    style KCNK18 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNK18 in their description or question text

No additional research found