gene

EPILEPSY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPILEPSY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2744Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

Summary

EPILEPSY is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS. Connected to 508 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	EPILEPSY
Full Name	Hippocampal CA3 Pyramidal Neurons in Epilepsy
Aliases	Seizure disorder, Epileptic syndrome
Protein Type	Cell Type
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer Disease, Alzheimer'S Disease
Interactions	ALZHEIMER'S DISEASE, AMYLOID, ALZHEIMER, NEUROINFLAMMATION, MICROGLIA, ERBB4
KG Connections	1552 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Hippocampal CA3 Pyramidal Neurons in Epilepsy

cell · 3155 words

→

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

flowchart TD
    EPILEPSY(["EPILEPSY"])
    Epilepsy["Epilepsy"]
    Als["Als"]
    Inflammation["Inflammation"]
    Neurodegeneration["Neurodegeneration"]
    ALZHEIMER_S_DISEASE(["ALZHEIMER'S DISEASE"])
    ALZHEIMER(["ALZHEIMER"])
    Mtor["Mtor"]
    MTOR(["MTOR"])
    Alzheimer["Alzheimer"]
    Parkinson["Parkinson"]
    Neuroinflammation["Neuroinflammation"]

    EPILEPSY -->|"associated with"| Epilepsy
    EPILEPSY -->|"therapeutic target"| Als
    EPILEPSY -->|"therapeutic target"| Epilepsy
    EPILEPSY -->|"activates"| Inflammation
    EPILEPSY -->|"activates"| Als
    EPILEPSY -->|"activates"| Neurodegeneration
    EPILEPSY -->|"associated with"| ALZHEIMER_S_DISEASE
    EPILEPSY -->|"associated with"| ALZHEIMER
    EPILEPSY -->|"therapeutic target"| Mtor
    EPILEPSY -->|"therapeutic target"| MTOR
    ALZHEIMER_S_DISEASE -->|"associated with"| EPILEPSY
    EPILEPSY -->|"associated with"| Alzheimer
    EPILEPSY -->|"causes"| Epilepsy
    EPILEPSY -->|"associated with"| Parkinson
    EPILEPSY -->|"activates"| Neuroinflammation

    style EPILEPSY fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1321)

Target	Relation	Type	Str
Epilepsy	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Epilepsy	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
Als	activates	disease	1.00
Mtor	therapeutic_target	pathway	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
Mtor	therapeutic_target	pathway	1.00
MTOR	therapeutic_target	gene	1.00
Alzheimer	associated_with	disease	0.95
Alzheimer	associated_with	disease	0.95
Epilepsy	causes	disease	0.95
Parkinson	associated_with	disease	0.95
Neuroinflammation	activates	disease	0.95
Neurodegeneration	activates	disease	0.95
Alzheimer	therapeutic_target	disease	0.95
Sudden Unexpected Death in Epilepsy	contributes_to	disease	0.95
temporal lobe	affects	brain_region	0.90
neurons	affects	cell_type	0.90
hippocampus	affects	brain_region	0.90
cortex	affects	brain_region	0.90
astrocytes	affects	cell_type	0.90
microglia	affects	cell_type	0.90
oxidative stress response	involves	pathway	0.90
neural stem cells	affects	cell_type	0.90
Oxidative Stress	therapeutic_target	pathway	0.90
PARKINSON	associated_with	gene	0.90
ASTROCYTE	activates	gene	0.90
ALZHEIMER	therapeutic_target	gene	0.90
Als	associated_with	disease	0.85
Parkinson	associated_with	disease	0.85
Epilepsy	contributes_to	disease	0.85
Epilepsy	regulates	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Neuroinflammation	therapeutic_target	disease	0.85
Neuroinflammation	activates	disease	0.85
Parkinson	therapeutic_target	disease	0.85
Alzheimer	therapeutic_target	disease	0.85
Als	therapeutic_target	disease	0.85
Als	associated_with	disease	0.85
Neurodegeneration	therapeutic_target	disease	0.85
glutamate signaling	involves	pathway	0.80
glutamate receptor	involves	receptor	0.80
PI3K-AKT-mTOR signaling	involves	pathway	0.80
pyroptosis	involves	pathway	0.80
neuron excitement	causes	biological_process	0.80

Incoming (1423)

Source	Relation	Type	Str
MTOR	therapeutic_target	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
EPILEPSY	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
EPILEPSY	therapeutic_target	gene	1.00
NEURODEGENERATION	activates	gene	1.00
NEURODEGENERATION	associated_with	gene	0.98
ASTROCYTES	activates	gene	0.95
APOPTOSIS	activates	gene	0.95
OXIDATIVE STRESS	therapeutic_target	gene	0.95
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.95
NEURODEGENERATION	therapeutic_target	gene	0.95
ALZHEIMER	associated_with	gene	0.95
EPILEPSY	causes	gene	0.95
PARKINSON	associated_with	gene	0.95
ASTROCYTE	activates	gene	0.95
ALZHEIMER	therapeutic_target	gene	0.95
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.95
Tuberous Sclerosis Complex	causes	disease	0.95
CORTEX	interacts_with	brain_region	0.95
Antiseizure Medications	treats	drug	0.95
GABRA1	causes	gene	0.95
GABRG2	causes	gene	0.95
MICROGLIA	implicated_in	cell_type	0.95
everolimus	treats	drug	0.90
Ih Current	associated_with	mechanism	0.90
MTOR	involved_in	gene	0.90
Neuroinflammation	involved_in	process	0.90
Glioblastoma Multiforme	causes	disease	0.90
AUTOPHAGY GENE MUTATIONS	causes	gene	0.90
HCN1 MUTATIONS	causes	gene	0.90
Inhibitory Synapse Elimination	contributes_to	process	0.90
Glioblastoma Multiforme	associated_with	disease	0.90
Autophagy	associated_with	pathway	0.90
ASTROCYTES	associated_with	cell_type	0.90
M305L	risk_factor_for	biomarker	0.90
D401H	risk_factor_for	biomarker	0.90
RLN1	associated_with	protein	0.90
HMGB1	biomarker_for	protein	0.90
Neuroinflammatory Pathways	involved_in	pathway	0.90
NEUROINFLAMMATION	therapeutic_target	gene	0.85
PARKINSON'S DISEASE	associated_with	gene	0.85
MICROGLIA	activates	gene	0.85
EPILEPSY	contributes_to	gene	0.85
AUTOPHAGY	activates	gene	0.85
EPILEPSY	regulates	gene	0.85
Propofol	treats	drug	0.85
HCN1 Epilepsy Mutants	risk_factor_for	biomarker	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do P/Q channel deficits paradoxically increase thalamic excitability despite

synaptic biology | 2026-04-14 | 1 hypotheses Top: 0.526

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EPILEPSY

Understanding Entity Pages

Summary

Wiki Pages (21)

Hippocampal CA3 Pyramidal Neurons in Epilepsy

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Device Therapies Comparison for CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

GRIA3 Gene

Astrocyte Reactivity Mechanism

CNTN5 — Contactin 5

Autophagy Mechanisms

ncam2

gabaergic-dysfunction

CNTN4 — Contactin 4

blood-brain-barrier

nf1-protein

Niemann-Pick Disease Type C (NPC)

Traumatic Brain Injury and Neurodegeneration Pathway

Excitotoxicity in Neurodegeneration

Neuronal Ceroid Lipofuscinosis (NCL)

Neuroprotection Strategies in Neurodegeneration

MACF1 — Microtubule-actin crosslinking factor 1

Angelman Syndrome