protein

KDM2A

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about KDM2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for KDM2A Protein

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🔬 Protein Info

Gene Symbol	Lysine Demethylase 2A
Chromosome	11q13.1
Protein Type	Fe(II)/2-oxoglutarate-dependent dioxygenase
Function	is a histone demethylase that specifically removes methyl groups from histone H3 at lysine 36 (H3K36).
Primary Expression	Ubiquitous, highest in brain and testis
Molecular Weight	130 kDa
UniProt ID	Q9Y2K2
NCBI Gene ID	22992
Ensembl ID	ENSG00000107140
OMIM	605469
Primary substrate	H3K36me2 (dimethylated lysine 36 on histone H3)
Secondary substrates	H3K36me1, H3K36me0
Weak activity	H3K4me3 (trimethylated lysine 4)
NuRD Complex	Associates with the nucleosome remodeling and deacetylase (NuRD) complex to coordinate chromatin remodeling and transcriptional repression
SCF Complex	Incorporates into SCF E3 ubiquitin ligase complexes for protein turnover
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KDM2A — AlphaFold Q9Y2K2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KDM2A Gene

gene · 1814 words

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KDM2A Protein

protein · 796 words

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Pathway Diagram

graph TD
    KDM2A["KDM2A"]
    neurodegeneration["neurodegeneration"]
    KDM2A -->|"implicated_in"| neurodegeneration
    style KDM2A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning KDM2A in their description or question text

No additional research found