Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KIF3C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KIF3C encodes a subunit of the kinesin-2 motor protein complex, mediating anterograde axonal transport in neurons
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| Gene Symbol | KIF3C |
| Full Name | Kinesin Family Member 3C |
| Chromosome | 2p23.3 |
| Function | is a neuronal kinesin motor protein that functions as a subunit of the heterotrimeric kinesin-2 complex. |
| Molecular Weight | 80 kDa |
| UniProt ID | [O14782](https://www.uniprot.org/uniprot/O14782) |
| Ensembl ID | ENSG00000101955 |
| GeneCards | KIF3C |
| Human Protein Atlas | KIF3C |
| Motor domains | Two catalytic heads bind microtubules and generate force via ATP hydrolysis |
| Coiled-coil stalk | Mediates dimerization of the motor subunits |
| Cargo-binding domain | Binds to KAP3 (Kinesin-associated protein) for cargo attachment |
| Tail domain | Provides regulation through autoinhibition |
| Anterograde transport | Movement toward microtubule plus ends (cell periphery) |
| Processive movement | Can take hundreds of steps without dissociating, with step size of ~8nm |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KIF3C["KIF3C"]
neurodegeneration["neurodegeneration"]
KIF3C -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KIF3C in their description or question text
No additional research found