protein

LIMP-2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIMP-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

1Hypotheses

1Analyses

1Outgoing

1Incoming

0Experiments

1Debates

Summary

Page for LIMP-2 Protein

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🔬 Protein Info

Gene Symbol	LIMP
Chromosome	4q21.1
Function	The discovery that LIMP-2 mediates the mannose-6-phosphate-independent trafficking of GCase to lysosomes represented a paradigm shift in our understanding of lysosomal enzyme targeting.
GeneCards	LIMP
Human Protein Atlas	LIMP
Interactions	LAMP2
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

LIMP-2 Protein

protein · 1745 words

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LIMP-2 Protein

protein · 1592 words

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Pathway Diagram

graph TD
    LIMP_2["LIMP-2"]
    LAMP2["LAMP2"]
    LAMP2 -->|"activates"| LIMP_2
    style LIMP_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
GBA lysosomal targeting	regulates	process	0.90

Incoming (1)

Source	Relation	Type	Str
LAMP2	activates	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Glucosylceramide accumulation nucleates alpha-synuclein aggr	0.525	Parkinson's disease	GBA-Synuclein Loop Therapeutics for PD

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.645

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning LIMP-2 in their description or question text

No additional research found