protein

LAMP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAMP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1101Connections

7Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

5Debates

Summary

LAMP2 (Lysosomal-Associated Membrane Protein 2): essential for autophagy, chaperone-mediated autophagy, and Danon disease

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🔬 Protein Info

Gene Symbol	LAMP2
Aliases	Lysosomal-Associated Membrane Protein 2
Chromosome	Xq24
Protein Family	LAMP family
Function	LAMP2 encodes Lysosomal Associated Membrane Protein 2, a major lysosomal membrane glycoprotein essential for lysosomal function, autophagy, and chaperone-mediated autophagy (CMA).
Molecular Weight	45 kDa
Amino Acids	410 aa
Pathways	Apoptosis, Autophagy, Chaperone, Lysosomal Degradation, Mtor
UniProt ID	P13473
Ensembl ID	ENSG00000143106
GeneCards	LAMP2
Human Protein Atlas	LAMP2
Associated Diseases	Als, Alzheimer, APOPTOSIS, AUTOPHAGY, Cancer
Known Drugs/Compounds	quercetin, rapamycin, RAPAMYCIN, statins
Interactions	ACLY, ACOX1, ACTB, Adiponectin, ADIPOQ, AGING
SciDEX Hypotheses	LAMP2A Liquid-Liquid Phase Separation Defects in D SNCA Oligomer Binding to LAMP2A Cytosolic Tail Pre
KG Connections	1100 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LAMP2 — AlphaFold P13473 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    LAMP2(["LAMP2"])
    TMEM175(["TMEM175"])
    Lysosomal_pH_Homeostasis("Lysosomal pH Homeostasis")
    Lysosomal_Acidification("Lysosomal Acidification")
    chaperone_mediated_autophagy("chaperone-mediated autophagy")
    Autophagy["Autophagy"]
    CKB(["CKB"])
    TFEB["TFEB"]
    Inflammation["Inflammation"]
    Als["Als"]
    LAMP2A(["LAMP2A"])
    AUTOPHAGY(["AUTOPHAGY"])
    TNF__(["TNF-Alpha"])

    LAMP2 -->|"interacts with"| TMEM175
    LAMP2 -.->|"inhibits"| TMEM175
    LAMP2 -->|"regulates"| Lysosomal_pH_Homeostasis
    LAMP2 -->|"associated with"| Lysosomal_Acidification
    LAMP2 -->|"participates in"| chaperone_mediated_autophagy
    LAMP2 -->|"involved in"| Autophagy
    CKB -->|"interacts with"| LAMP2
    TFEB -->|"upregulates"| LAMP2
    LAMP2 -->|"activates"| Inflammation
    LAMP2 -->|"activates"| Als
    LAMP2 -->|"encodes"| LAMP2A
    LAMP2 -->|"regulates"| chaperone_mediated_autophagy
    LAMP2 -->|"activates"| AUTOPHAGY
    LAMP2 -->|"activates"| Autophagy
    LAMP2 -->|"activates"| TNF__

    style LAMP2 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (624)

Target	Relation	Type	Str
LAMP2	encodes	protein	0.00
Danon Disease	associated_with	disease	0.98
Danon Disease	causes	disease	0.95
Lysosome Biogenesis	involved_in	process	0.95
AUTOPHAGY	associated_with	process	0.95
TMEM175	inhibits	protein	0.95
TMEM175	interacts_with	protein	0.95
Lysosomal Ph Homeostasis	regulates	process	0.95
Lysosomal Acidification	associated_with	process	0.90
autophagy pathway	participates_in	pathway	0.90
Lysosomal pH Homeostasis	regulates	process	0.90
autophagic vacuole accumulation	regulates	phenotype	0.90
Lysosomal Glycogen Storage Disease	causes	disease	0.90
Autophagic Vacuole Accumulation	contributes_to	phenotype	0.88
glycogen storage	regulates	process	0.85
Parkinson'S Disease	involved_in	disease	0.85
lysosomal hydrolytic function	promotes	process	0.85
Lysosomal Dysfunction	associated_with	phenotype	0.85
heart	expressed_in	cell_type	0.80
chaperone mediated autophagy	participates_in	pathway	0.80
autophagy-lysosomal pathway	involved_in	pathway	0.80
lysosomal membrane integrity	associated_with	process	0.80
skeletal muscle	expressed_in	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
RAS	regulates	gene	0.80
ULK1	regulates	gene	0.80
MAP1LC3B	regulates	gene	0.80
MTOR	regulates	gene	0.80
Autophagy	associated_with	process	0.80
cholesterol homeostasis	regulates	process	0.75
Inflammation	activates	disease	0.75
Als	activates	disease	0.75
Autophagy	activates	pathway	0.70
RUBCNL	activates	gene	0.70
neural stem cells	activates	cell_type	0.70
Autophagy	regulates	pathway	0.70
AUTOPHAGY	regulates	gene	0.70
TNF-Α	activates	gene	0.70
TAU	activates	protein	0.70
TAU	degrades	protein	0.70
AUTOPHAGY	activates	gene	0.70
Parkinson's Disease	associated_with	disease	0.70
blood-brain barrier	participates_in	pathway	0.70
GENES	associated_with	gene	0.70
MAPK signaling	participates_in	pathway	0.70
chaperone-mediated autophagy	regulates	process	0.70
LAMP2A	encodes	protein	0.70
astrocytes	expressed_in	cell_type	0.70
Tumor	associated_with	disease	0.65
Ms	activates	disease	0.65

Incoming (477)

Source	Relation	Type	Str
LAMP2	encodes	gene	0.00
CKB	interacts_with	gene	0.80
TFEB	upregulates	entity	0.80
rapamycin	targets	drug	0.80
ATG	activates	gene	0.80
LYSOSOME	activates	gene	0.70
BECN1	regulates	gene	0.70
GABARAP	regulates	gene	0.70
TNF	activates	gene	0.70
GABA	regulates	gene	0.70
AMPK	regulates	gene	0.70
TFEB	regulates	protein	0.70
statins	inhibits	drug	0.70
LAMP1	interacts_with	gene	0.70
LAMP1	associated_with	gene	0.65
CTSD	phosphorylates	gene	0.65
MITOPHAGY	regulates	phenotype	0.65
GFAP	co_discussed	gene	0.65
NEURONS	produces	cell_type	0.65
PARK7	causes	gene	0.65
BECLIN1	associated_with	gene	0.60
LAMP2A	therapeutic_target	gene	0.60
BAX	activates	gene	0.60
PI3K	expressed_in	gene	0.60
BECLIN1	inhibits	gene	0.60
P62	inhibits	gene	0.60
AKT	inhibits	gene	0.60
LC3	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
KAT7	activates	gene	0.60
CANX	interacts_with	gene	0.60
APP	activates	gene	0.60
TFEB	activates	gene	0.60
DNM1L	activates	entity	0.60
GABARAP	activates	entity	0.60
GABARAPL1	activates	entity	0.60
CTSB	inhibits	gene	0.60
PPP3CB	expressed_in	gene	0.60
P62	expressed_in	gene	0.60
IL4	inhibits	gene	0.60
HTT	associated_with	gene	0.60
CD163	expressed_in	gene	0.60
GENES	therapeutic_target	gene	0.60
AMPK	associated_with	gene	0.60
LC3B	associated_with	gene	0.60
GLIOBLASTOMA	co_discussed	gene	0.60
AMPK	co_discussed	gene	0.60
AMYLOID	co_discussed	gene	0.60
CYTOKINES	inhibits	gene	0.60
INFLAMMATION	activates	gene	0.60

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergi	0.783	neurodegeneration	-
GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9	0.750	neurodegeneration	-
LAMP2A-Mediated Autophagy Enhancement Blocks Alpha-Synuclein	0.745	neurodegeneration	Test
SNCA Oligomer Binding to LAMP2A Cytosolic Tail Prevents Tors	0.733	neurodegeneration	-
Lysosomal Acidification Failure: Convergent GBA1/LAMP2A–medi	0.700	neurodegeneration	-

SNCA Aggregation Hijacks the Endosomal Sorting Complex Requi	0.690	neurodegeneration	-
LAMP2A Upregulation to Enhance Chaperone-Mediated Autophagy	0.000	proteomics	Quantitative proteomics of the aging syn