protein

LAMP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAMP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1117Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

LAMP2 (Lysosomal-Associated Membrane Protein 2): essential for autophagy, chaperone-mediated autophagy, and Danon disease

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🔬 Protein Info

Gene Symbol	LAMP2
Full Name	Lysosomal Associated Membrane Protein 2
Aliases	Lysosomal-Associated Membrane Protein 2
Chromosome	Xq24
Protein Family	LAMP family
Function	LAMP2 encodes Lysosomal Associated Membrane Protein 2, a major lysosomal membrane glycoprotein essential for lysosomal function, autophagy, and chaperone-mediated autophagy (CMA).
Molecular Weight	45 kDa
Amino Acids	410 aa
Pathways	Apoptosis, Autophagy, Chaperone, Lysosomal Degradation, Mtor
UniProt ID	P13473
NCBI Gene ID	3990
Ensembl ID	ENSG00000143106
OMIM	300256
GeneCards	LAMP2
Human Protein Atlas	LAMP2
Associated Diseases	ALS, APOPTOSIS, AUTOPHAGY, Alzheimer, Cancer
Known Drugs/Compounds	RAPAMYCIN, statins, quercetin, rapamycin
Interactions	PLIN3, BECN1, GRK2, FOXO1, NR1H3, MAP3K5
KG Connections	1117 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LAMP2 — AlphaFold P13473 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    LAMP2(["LAMP2"])
    TMEM175(["TMEM175"])
    Lysosomal_pH_Homeostasis("Lysosomal pH Homeostasis")
    Lysosomal_Acidification("Lysosomal Acidification")
    chaperone_mediated_autophagy("chaperone-mediated autophagy")
    Autophagy["Autophagy"]
    CKB(["CKB"])
    TFEB["TFEB"]
    Inflammation["Inflammation"]
    Als["Als"]
    LAMP2A(["LAMP2A"])
    AUTOPHAGY(["AUTOPHAGY"])
    TNF__(["TNF-Alpha"])

    LAMP2 -->|"interacts with"| TMEM175
    LAMP2 -.->|"inhibits"| TMEM175
    LAMP2 -->|"regulates"| Lysosomal_pH_Homeostasis
    LAMP2 -->|"associated with"| Lysosomal_Acidification
    LAMP2 -->|"participates in"| chaperone_mediated_autophagy
    LAMP2 -->|"involved in"| Autophagy
    CKB -->|"interacts with"| LAMP2
    TFEB -->|"upregulates"| LAMP2
    LAMP2 -->|"activates"| Inflammation
    LAMP2 -->|"activates"| Als
    LAMP2 -->|"encodes"| LAMP2A
    LAMP2 -->|"regulates"| chaperone_mediated_autophagy
    LAMP2 -->|"activates"| AUTOPHAGY
    LAMP2 -->|"activates"| Autophagy
    LAMP2 -->|"activates"| TNF__

    style LAMP2 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (635)

Target	Relation	Type	Str
Danon Disease	associated_with	disease	0.98
TMEM175	interacts_with	protein	0.95
TMEM175	inhibits	protein	0.95
Lysosome Biogenesis	involved_in	process	0.95
Lysosomal Ph Homeostasis	regulates	process	0.95
Danon Disease	causes	disease	0.95
AUTOPHAGY	involved_in	process	0.95
Lysosomal pH Homeostasis	regulates	process	0.90
Lysosomal Glycogen Storage Disease	causes	disease	0.90
Lysosomal Acidification	promotes	process	0.90
autophagic vacuole accumulation	regulates	phenotype	0.90
autophagy pathway	participates_in	pathway	0.90
Autophagic Vacuole Accumulation	contributes_to	phenotype	0.88
Lysosomal Acidification	associated_with	process	0.85
Lysosomal Dysfunction	associated_with	phenotype	0.85
lysosomal hydrolytic function	promotes	process	0.85
glycogen storage	regulates	process	0.85
Parkinson'S Disease	involved_in	disease	0.85
chaperone mediated autophagy	participates_in	pathway	0.80
MAP1LC3B	regulates	gene	0.80
MTOR	regulates	gene	0.80
ULK1	regulates	gene	0.80
autophagy-lysosomal pathway	involved_in	pathway	0.80
lysosomal membrane integrity	associated_with	process	0.80
heart	expressed_in	cell_type	0.80
skeletal muscle	expressed_in	cell_type	0.80
Autophagy	involved_in	process	0.80
RAS	regulates	gene	0.80
neural stem cells	regulates	cell_type	0.80
cholesterol homeostasis	regulates	process	0.75
Inflammation	activates	disease	0.75
Als	activates	disease	0.75
LAMP2A	encodes	protein	0.70
chaperone-mediated autophagy	regulates	process	0.70
TAU	degrades	protein	0.70
TAU	activates	protein	0.70
AUTOPHAGY	activates	gene	0.70
Autophagy	activates	pathway	0.70
TNF-Α	activates	gene	0.70
GENES	associated_with	gene	0.70
AUTOPHAGY	regulates	gene	0.70
Autophagy	regulates	pathway	0.70
Parkinson's Disease	associated_with	disease	0.70
RUBCNL	activates	gene	0.70
neural stem cells	activates	cell_type	0.70
astrocytes	expressed_in	cell_type	0.70
blood-brain barrier	participates_in	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
TAU	associated_with	gene	0.65
VCP	associated_with	gene	0.65

Incoming (482)

Source	Relation	Type	Str
CKB	interacts_with	gene	0.80
TFEB	upregulates	entity	0.80
ATG	activates	gene	0.80
rapamycin	targets	drug	0.80
statins	inhibits	drug	0.70
TFEB	regulates	protein	0.70
TNF	activates	gene	0.70
GABARAP	regulates	gene	0.70
BECN1	regulates	gene	0.70
LAMP1	co_expressed_with	gene	0.70
LYSOSOME	activates	gene	0.70
GABA	regulates	gene	0.70
AMPK	regulates	gene	0.70
LAMP1	associated_with	gene	0.65
CTSD	phosphorylates	gene	0.65
GFAP	co_discussed	gene	0.65
PARK7	causes	gene	0.65
NEURONS	produces	cell_type	0.65
MITOPHAGY	regulates	phenotype	0.65
VAMP8	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
RTN3	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
FYCO1	associated_with	gene	0.60
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SDC1	associated_with	gene	0.60
P62	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
STX17	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LAMP2

Understanding Entity Pages

Summary

Wiki Pages (21)

LAMP2 Gene

CLCN10 — Chloride Voltage-Gated Channel 10

Autophagy Mechanisms

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

ATP13A2 Lysosomal Dysfunction Pathway in Parkinson's Disease

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

Lysosomal Dysfunction in Neurodegeneration

Retromer Dysfunction in Corticobasal Syndrome

autophagy-lysosomal-alzheimers

Tunneling Nanotubes in Neurodegeneration

Granulovacuolar Bodies: Neuronal Defense Mechanism Against Tau Pathology

MSA Genetics and Risk Factors

ATP13A2 — ATPase Cation Transporting 13A2

Endosomal Trafficking Pathway

lmx1b

Autophagy-Lysosomal Pathway in Parkinson's Disease

autophagy-lysosome-dysfunction

Chaperone-Mediated Autophagy in Neurodegeneration

MAP1LC3A Gene

TMEM175 Protein

Metabolic-Energetic Restoration: GLP-1 + TFEB Activator Combination