entity

LXA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LXA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

2Analyses

19Outgoing

4Incoming

0Experiments

2Debates

No AI portrait yet

Outgoing (19)

Target	Relation	Type	Str
astrocytic_neuroprotection	activates	mechanism	1.00
phagocytosis	involved_in	mechanism	0.85
phagocytosis	associated_with	mechanism	0.85
neuroinflammation	mediates	mechanism	0.85
microglial_activation	inhibits	mechanism	0.82
microglial_activation	modulates	mechanism	0.80
neuroinflammation	contributes_to	mechanism	0.80
ocular surface health	contributes_to	unknown	0.80
neuroinflammation	inhibits	mechanism	0.76
GPR32	binds	protein	0.75
ALX/FPR2 receptor downregulation	causes	mechanism	0.70
β-arrestin2 recruitment at ALX/FPR2	inhibits	mechanism	0.70
A1 astrocytes	inhibits	cell_type	0.70
blood-brain barrier integrity	preserves	process	0.70
reactive astrocytes	modulates	cell_type	0.70
A1 astrocyte conversion	prevents	phenotype	0.70
blood-brain barrier integrity	protective_against	process	0.70
A1_astrocyte_phenotype	inhibits	phenotype	0.50
blood-brain_barrier_integrity	protective_against	process	0.50

Incoming (4)

Source	Relation	Type	Str
ALOX15	regulates	gene	0.95
GPR32	binds	protein	0.90
ALOX15	encodes	gene	0.88
ALOX15	associated_with	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Do SPM receptors undergo desensitization with chronic agonist treatment, prevent

pharmacology | 2026-04-11 | 0 hypotheses

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate highlighted receptor desensitization as a critical concern for SPM re

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

What are the mechanisms underlying neuroinflammation resolution mechanisms and p

closed · Rounds: 5 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning LXA4 in their description or question text

No additional research found