biological_process

neuroinflammation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about neuroinflammation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10916Connections

5Hypotheses

28Analyses

50Outgoing

50Incoming

Summary

A mechanism referenced in 1 knowledge graph relationship. Key connections: contributes_to alzheimers (disease).

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🧬 Biological Process Info

Name	Neuroinflammation PET Imaging in CBS/PSP
Summary	PET imaging of neuroinflammation in corticobasal syndrome and progressive supranuclear palsy - TSPO, microglial activation, MAO-B imaging, and MRS
Key Genes/Proteins	NLRP3, STING, RIPK1, TREM2, ACOD1, IL1B
Related Diseases	neuronal damage, Parkinson's Disease, Multiple Sclerosis, A1 astrocyte phenotype
Related Pathways	NF-κB, cGAS-STING-NF-κB signaling, NF-κB pathway
Linked Hypotheses	6 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

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Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

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Progressive Supranuclear Palsy (PSP)

disease · 12907 words

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Pathway Diagram

graph TD
    Trigger["Pathology Trigger"] -->|"Activates"| Microglia["Microglia"]
    Trigger -->|"Activates"| Astrocytes["Astrocytes"]
    Microglia -->|"Release"| Cytokines["Pro-inflammatory Cytokines"]
    Astrocytes -->|"Release"| Reactivity["Reactive Molecules"]
    Cytokines -->|"Include"| TNF["TNF-alpha, IL-1beta, IL-6"]
    Reactivity -->|"Include"| ROS["ROS, NO"]
    TNF -->|"Amplify"| Inflammation["Chronic Inflammation"]
    ROS -->|"Cause"| Damage["Oxidative Damage"]
    Inflammation -.Contributes to.-> Neurodegeneration["Neurodegeneration"]

Outgoing (4345)

Target	Relation	Type	Str
neuronal damage	causes	phenotype	0.95
Parkinson's Disease	drives	disease	0.95
Multiple Sclerosis	drives	disease	0.95
neurodegeneration	promotes	process	0.90
depression	causes	disease	0.90
spinal cord	affects	brain_region	0.90
ferroptosis	involves	pathway	0.90
purinergic receptor	involves	receptor	0.90
cGAS-STING	involves	pathway	0.90
neuronal damage	contributes_to	process	0.90
midbrain	involved_in	brain_region	0.90
neurodegeneration	contributes_to	process	0.90
neurodegeneration	drives	process	0.90
cortex	affects	brain_region	0.90
astrocytes	affects	cell_type	0.90
microglia	affects	cell_type	0.90
macrophages	affects	cell_type	0.90
NF-kB signaling	involves	pathway	0.90
neurons	affects	cell_type	0.90
unfolded protein response	involves	pathway	0.90
lipid metabolism	involves	pathway	0.90
oligodendrocytes	affects	cell_type	0.90
PI3K-AKT-mTOR signaling	involves	pathway	0.90
blood-brain barrier	affects	brain_region	0.90
dopaminergic neurons	affects	cell_type	0.90
hippocampus	affects	brain_region	0.90
pyroptosis	involves	pathway	0.90
MAPK signaling	involves	pathway	0.90
synaptic plasticity	involves	pathway	0.90
JAK-STAT signaling	involves	pathway	0.90
neural stem cells	affects	cell_type	0.90
oxidative stress	causes	process	0.90
dopaminergic neurons	causes	cell_type	0.90
blood-brain barrier	associated_with	brain_region	0.90
Alzheimer's Disease	associated_with	disease	0.90
Alzheimer's Disease	causes	disease	0.90
Parkinson's Disease	causes	disease	0.90
dopaminergic neurodegeneration	contributes_to	process	0.88
secondary brain injury	contributes_to	disease	0.88
Alzheimer's Disease	contributes_to	disease	0.88
depression	promotes	disease	0.85
cognitive decline	promotes	phenotype	0.85
circadian regulation	involves	pathway	0.85
Alzheimer's Disease	drives	disease	0.85
Parkinson's Disease	contributes_to	disease	0.85
inhibitory synaptic transmission	inhibits	process	0.84
neurodegenerative diseases	promotes	disease	0.82
calcium signaling	involves	pathway	0.80
white matter	affects	brain_region	0.80
glutamate signaling	involves	pathway	0.80

Incoming (6571)

Source	Relation	Type	Str
NLRP3	promotes	protein	0.95
STING	promotes	protein	0.95
RIPK1	regulates	protein	0.95
DAMPs	associated_with	compound	0.95
TREM2	mediates	gene	0.95
mitochondrial dysfunction	drives	process	0.95
NF-κB	activates	pathway	0.95
cGAS-STING-NF-κB signaling	promotes	pathway	0.94
ACOD1	inhibits	gene	0.94
NF-κB pathway	promotes	pathway	0.93
A1 astrocyte phenotype	associated_with	phenotype	0.92
IL1B	promotes	protein	0.92
TNF-α	promotes	protein	0.92
defective mitophagy	causes	phenotype	0.90
TREM1	causes	protein	0.90
NLRP3	associated_with	gene	0.90
APOE4	promotes	gene	0.90
NLRP3 inflammasome	promotes	pathway	0.90
T3 (triiodothyronine)	inhibits	drug	0.90
E4A	prevents	drug	0.90
skeletal muscle	regulates	cell_type	0.90
ADK	promotes	protein	0.90
H-EV	inhibits	drug	0.90
type I interferon response	promotes	process	0.90
APOE ε2	improves	gene	0.90
TREM2	activates	gene	0.90
GFAP	activates	gene	0.90
NLRP3	inhibits	gene	0.90
NLRP3	regulates	gene	0.90
STING	activates	gene	0.90
BDNF	inhibits	gene	0.90
IL-6 deficiency	inhibits	process	0.90
NLRP3	plays_crucial_role	protein	0.90
PARTHANATOS	plays_pivotal_role	process	0.90
TBK1	does_not_cause	gene	0.90
choroid plexus	synergizes_with	tissue	0.90
GPR34	promotes	protein	0.90
oligodendrocyte	drives	cell_type	0.90
cysteinyl leukotrienes	mediates	compound	0.90
ALOX5 pathway	regulates	pathway	0.90
NLRP3	drives	protein	0.90
SASP	promotes	process	0.90
IL1B	drives	protein	0.90
Lgals3	drives	protein	0.90
lipopolysaccharide	associated_with	compound	0.90
cytokine/chemokine network	associated_with	pathway	0.90
chemokines	regulates	protein	0.90
autophagy	modulates	process	0.90
NLRP3 inflammasome	drives	protein	0.90
Jak/Stat	activates	pathway	0.90

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone	0.645	neurodegeneration	What are the precise temporal dynamics o
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation	0.605	neuroinflammation	What molecular mechanisms drive the tran
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic
Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio	0.486	translational neuroscience	Which metabolic biomarkers can distingui
Cardiovascular-Neuroinflammation Crosstalk Interruption	0.437	Alzheimer's disease	Neuroinflammation and microglial priming

Mentioning Analyses (28)

Scientific analyses that reference this entity

What molecular mechanisms drive the transition from acute to persistent neuroinf

neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.567

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.596

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632

What molecular mechanisms underlie the dose-dependent protective effects of the

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.473

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q-Targeted Microglial Membrane Camouflaged Nanolipid Carriers for S [PMID:41114949]	Ding YN, Li MQ, Ding PT, Wang P, Guan PP	Nano letters	2026	1
Systemic inflammation as a central player in the initiation and development of A [PMID:40841660]	Bayraktaroglu I, Ortí-Casañ N, Van Dam D	Immunity & ageing : I & A	2025	1
Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibi [PMID:40050873]	Ma J, Tian Y, Du C, Zhu Y, Huang W, Ding	Journal of nanobiotechnology	2025	1
Interactions between antidiabetes medications and heart-brain axis. [PMID:39639832]	Ong LT, Sia CH	Current opinion in endocrinolo	2025	1
The Molecular Mechanisms of Cognitive Dysfunction in Long COVID: A Narrative Rev [PMID:40507911]	Popa E, Popa AE, Poroch M, Poroch V, Ung	International journal of molec	2025	1
Air pollution, glymphatic impairment, and Alzheimer's disease. [PMID:37777345]	Hussain R, Graham U, Elder A, Nedergaard	Trends in neurosciences	2023	0
Molecular biomarkers for vascular cognitive impairment and dementia. [PMID:37957261]	Hosoki S, Hansra GK, Jayasena T, Poljak	Nature reviews. Neurology	2023	0

neuroinflammation

Understanding Entity Pages

Summary

Wiki Pages (21)