mechanism

phagocytosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about phagocytosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3235Connections

4Hypotheses

0Analyses

28Outgoing

50Incoming

Summary

A mechanism referenced in 3 knowledge graph relationships. Key connections: TREM2_protein (protein) promotes; promotes amyloid_clearance (mechanism); CD33 (gene) inhibits.

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⚙ Mechanism Info

Name	phagocytosis
Key Genes/Proteins	OPTN, PI3K, TREM2 risk variants, LC3, TREM2, Akt
Related Pathways	autophagy pathway, complement cascade
Linked Hypotheses	6 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Phagocytosis["Phagocytosis"] -->|"interacts"| Pyroptosis["Pyroptosis"]
    Microglia["Microglia"] -->|"activates"| Phagocytosis["Phagocytosis"]
    JUN["JUN"] -->|"protects against"| Phagocytosis["Phagocytosis"]
    APOE["APOE"] -->|"contributes to"| Phagocytosis["Phagocytosis"]
    RELN["RELN"] -->|"protects against"| Phagocytosis["Phagocytosis"]
    style Phagocytosis fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1264)

Target	Relation	Type	Str
synaptic_loss	causes	phenotype	0.64
TREM2	binds_to	gene	0.60
Cognitive Resilience	contributes_to	biological_process	0.60
PPARGC1A	activates	gene	0.55
RELN	activates	gene	0.55
SLC16A2	activates	gene	0.55
PRMT1	activates	gene	0.55
SRPK1	activates	gene	0.55
TGM2	activates	gene	0.55
PIEZO1 and KCNK2	activates	gene	0.55
ST6GAL1	activates	gene	0.55
PLA2G6	activates	gene	0.55
TFRC	activates	gene	0.55
TARDBP	activates	gene	0.55
SETX	activates	gene	0.55
RAB27A	activates	gene	0.55
ST3GAL2	activates	gene	0.55
PLCG2	activates	gene	0.55
SYK	activates	gene	0.55
senescence	associated_with	process	0.55
TREM2	debate_co_mention	gene	0.45
PHB2	debate_co_mention	gene	0.45
TARDBP	debate_co_mention	gene	0.45
TGM2	debate_co_mention	gene	0.45
RNA	debate_co_mention	gene	0.45
TREM2	co_mentioned	gene	0.40
VCP	co_mentioned	gene	0.40
RNA	co_mentioned	gene	0.40

Incoming (1971)

Source	Relation	Type	Str
microglial cells	involved_in	cell_type	0.95
microglia	involved_in	cell_type	0.95
microglia	activates	cell_type	0.90
macrophages	activates	cell_type	0.90
autophagy pathway	mediates	pathway	0.90
cGAMP	associated_with	compound	0.88
OPTN	regulates	protein	0.85
PI3K	promotes	protein	0.85
lamellipodia formation	mediates	process	0.85
TREM2 risk variants	inhibits	gene	0.80
complement cascade	mediates	pathway	0.80
LC3	activates	gene	0.80
TREM2	activates	gene	0.80
Akt	regulates	protein	0.80
microglia	associated_with	cell_type	0.80
C1Q	activates	protein	0.72
AKT	regulates	protein	0.70
autophagy	regulates	process	0.70
stroke	associated_with	disease	0.70
oxygen and nutrient deprivation	inhibits	process	0.70
autophagy	activates	pathway	0.70
C3	activates	gene	0.70
GPR37	activates	gene	0.70
TFEB	activates	gene	0.70
TET2	activates	gene	0.70
TREM2	associated_with	gene	0.70
TREM2	expressed_in	gene	0.70
CD33	activates	gene	0.70
TREM2	inhibits	gene	0.70
TREM2	regulates	gene	0.70
microglia	regulates	cell_type	0.70
microglia	protects_against	cell_type	0.70
microglia	inhibits	cell_type	0.70
astrocytes	activates	cell_type	0.70
oxidative stress response	mediates	pathway	0.70
CD33	inhibits	gene	0.60
APOE	protects_against	gene	0.60
APOE	regulates	gene	0.60
C3	regulates	gene	0.60
C3	inhibits	gene	0.60
C3	associated_with	gene	0.60
GPR37	regulates	gene	0.60
TREM2	interacts_with	gene	0.60
TYROBP	activates	gene	0.60
GSDME	activates	gene	0.60
CD8	activates	gene	0.60
SIRT1	activates	gene	0.60
PLIN3	activates	gene	0.60
PLIN2	activates	gene	0.60
MAP3K5	activates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Driven Microglial Metabolic Reprogramming in Synaptic P	0.638	neurodegeneration	Senolytic therapy for age-related neurod
Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in	0.458	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha	0.452	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Microglial TREM2-Mediated Tau Phagocytosis Impairment	0.441	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (18)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026
Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649]	Zhang J, St Pierre Schneider B, Muguerza	Am J Physiol Endocrinol Metab	2026
Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750]	Yang X, Zhao Y, Liu W, Feng J, Wu X et a	J Ethnopharmacol	2026
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvir [PMID:41576929]	Mateus-Tique J, Lakshmi A, Singh B, Iyer	Cancer Cell	2026
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026
TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393]	Feiten AF, Dahm K, Schlepckow K, van Len	Nat Commun	2026
Large-scale single-cell analysis and in silico perturbation reveal dynamic evolu [PMID:41617928]	Xia P, Shuang S, Fu D, Liu L, Yang D et	NPJ Precis Oncol	2026
Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant [PMID:41720086]	Zhao Q, Huang R, Wang C, Hu J, Nie R et	Cancer Cell	2026
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026
Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876]	Chen F, Xue Y, Ma X, Chen L, Shao Z et a	Adv Sci (Weinh)	2026
Correction to "A Strategy Involving Microporous Microneedles Integrated with CAR [PMID:41952643]	Unknown	Advanced materials (Deerfield	2026
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026
Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage d [PMID:41509917]	Choi C, Lee J, Park G, Namgoong S, Lee Y	iScience	2026
Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268]	["Srivastav Jyotsna", "Sharma Sachin"]	Frontiers in medicine	2025
Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy. [PMID:20301376]	Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa		1993

phagocytosis

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

nhp-validation-animal-model

Therapeutics

neuroinflammation

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

GSK-3β in Neurodegeneration

Growth Factor Therapies

Oligodendrocytes

Tau Spreading Mechanism

TREM2 Microglial Signaling Pathway in Neurodegeneration

dendritic-spines

DIAN-TU-001 Trial (NCT01760005)