Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Lysosomal function / degradation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Lysosomal Enzyme Trafficking Correction | 0.706 | neurodegeneration | Autophagy-lysosome pathway convergence a |
| Lysosomal Calcium Channel Modulation Therapy | 0.697 | neurodegeneration | Autophagy-lysosome pathway convergence a |
| Lysosomal Membrane Repair Enhancement | 0.685 | neurodegeneration | Autophagy-lysosome pathway convergence a |
| Mitochondrial-Lysosomal Contact Site Engineering | 0.668 | neurodegeneration | Autophagy-lysosome pathway convergence a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.863
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Live-cell microscopy of mitochondria-lysosome contacts and calcium dyn | exploratory | mucolipidosis type IV | 0.900 | 0.00 | cultured cells | proposed | N/A |
| Analysis of MLIV patient fibroblasts for contact dynamics and calcium | clinical | mucolipidosis type IV | 0.850 | 0.00 | human patient fibroblasts | proposed | N/A |
| Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Presymptomatic GRN Carrier Intervention Timing — Biomarker-Guided Ther | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Proteasome-Ubiquitin System Dysfunction Validation in Parkinson's Dise | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeu | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,730,000 |
| ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Validate Mitochondria-Lysosome Contact Site Dysfunction in PD | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Autophagy Enhancement Drug Screening for Neurodegeneration | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| MLCS Quantification in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591] | Rusmini P, Cortese K, Crippa V, Cristofa | Autophagy | 2019 | 2 |
| Designed endocytosis-inducing proteins degrade targets and amplify signals. [PMID:39322662] | Huang B, Abedi M, Ahn G, Coventry B, Sap | Nature | 2025 | 1 |
| Lactate accumulation drives hepatocellular carcinoma metastasis through facilita [PMID:40120799] | Jiang C, He X, Chen X, Huang J, Liu Y, Z | Cancer Lett | 2025 | 1 |
| α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral de [PMID:40934925] | Sitron CS, Trinkaus VA, Galesic A, Garha | Mol Cell | 2025 | 1 |
| Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and [PMID:38578235] | Mulligan RJ, Magaj MM, Digilio L, Redema | J Cell Sci | 2024 | 1 |
| IGF2 in memory, neurodevelopmental disorders, and neurodegenerative diseases. [PMID:37031050] | Alberini CM | Trends Neurosci | 2023 | 1 |
| TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signa [PMID:32972302] | Zhou C, Liang Y, Zhou L, Yan Y, Liu N, Z | Autophagy | 2021 | 1 |
| Role of the endolysosomal pathway and exosome release in tau propagation. [PMID:33582164] | Yan M, Zheng T | Neurochem Int | 2021 | 1 |
| MCOLN1/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc in [PMID:33890549] | Qi J, Xing Y, Liu Y, Wang MM, Wei X, Sui | Autophagy | 2021 | 1 |
| Mitochondria-lysosome contacts regulate mitochondrial Ca(2+) dynamics via lysoso [PMID:32703809] | Peng W, Wong YC, Krainc D | Proc Natl Acad Sci U S A | 2020 | 1 |
| Rab7a and Mitophagosome Formation. [PMID:30857122] | Tan EHN, Tang BL | Cells | 2019 | 1 |
| Compromised function of the ESCRT pathway promotes endolysosomal escape of tau s [PMID:31578281] | Chen JJ, Nathaniel DL, Raghavan P, Nelso | J Biol Chem | 2019 | 1 |
| Chloroquine modulates antitumor immune response by resetting tumor-associated ma [PMID:29491374] | Chen D, Xie J, Fiskesund R, Dong W, Lian | Nat Commun | 2018 | 1 |
| TRPML1: The Ca((2+))retaker of the lysosome. [PMID:28689729] | Di Paola S, Scotto-Rosato A, Medina DL | Cell Calcium | 2018 | 1 |
| Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate rec [PMID:19251056] | Brown J, Jones EY, Forbes BE | Vitam Horm | 2009 | 1 |
| TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition [PMID:41714729] | Weiden EM, Serianz Z, Klingl Y, Jörs S, | The EMBO journal | 2026 | 0 |
| YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA [PMID:41702019] | Chai J, Han L, Mo D, Bai Y, Yang Y et al | Redox Biol | 2026 | 0 |
| PAC regulates endo-, and exocytosis, and lysosomal-mitochondrial stress signalin [PMID:41559803] | Melek K, Steiner P, Kappel S, Gottschalk | Cell communication and signali | 2026 | 0 |
| A perilysosomal feedforward mechanism regulates starvation-induced calcium signa [PMID:41542926] | Giles J, Sesker A, Gonzalez M, Ferow A, | The FEBS journal | 2026 | 0 |
Multi-agent debates referencing this entity