MCOLN1

Understanding Entity Pages

This page aggregates everything SciDEX knows about MCOLN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

MCOLN1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 196 entities in the SciDEX knowledge graph.

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graph TD
    MCOLN1["MCOLN1"] -->|"Regulates"| lysosomal_hydrolytic_capacity["lysosomal hydrolytic capacity"]
    MCOLN1["MCOLN1"] -->|"Regulates"| autophagy["autophagy"]
    MCOLN1["MCOLN1"] -->|"Regulates"| zinc["zinc"]
    MCOLN1["MCOLN1"] -->|"Treats"| cancer["cancer"]
    MCOLN1["MCOLN1"] -->|"Associated With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MCOLN1["MCOLN1"] -->|"Activates"| Neurodegeneration["Neurodegeneration"]
    MCOLN1["MCOLN1"] -->|"Associated With"| Ataxia["Ataxia"]
    MCOLN1["MCOLN1"] -->|"Associated With"| Als["Als"]
    h_8ef34c4c["h-8ef34c4c"] -->|"Targets Gene"| MCOLN1["MCOLN1"]
    AMPK["AMPK"] -->|"Activates"| MCOLN1["MCOLN1"]
    PIKFYVE["PIKFYVE"] -->|"Regulates"| MCOLN1["MCOLN1"]
    TFEB["TFEB"] -->|"Upregulates"| MCOLN1["MCOLN1"]
    STIP1["STIP1"] -->|"Associated With"| MCOLN1["MCOLN1"]
    style MCOLN1 fill:#8d4900,color:#e0e0e0
    style lysosomal_hydrolytic_capacity fill:#607D8B,color:#e0e0e0
    style autophagy fill:#9C27B0,color:#e0e0e0
    style zinc fill:#0d47a1,color:#e0e0e0
    style cancer fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style Ataxia fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style h_8ef34c4c fill:#607D8B,color:#e0e0e0
    style AMPK fill:#0d47a1,color:#e0e0e0
    style PIKFYVE fill:#8d4900,color:#e0e0e0
    style TFEB fill:#8d4900,color:#e0e0e0
    style STIP1 fill:#8d4900,color:#e0e0e0